阿尔茨海默病患者皮质树突中的线粒体异常。

Mitochondrial abnormalities in cortical dendrites from patients with Alzheimer's disease.

作者信息

Saraiva A A, Borges M M, Madeira M D, Tavares M A, Paula-Barbosa M M

出版信息

J Submicrosc Cytol. 1985 Jul;17(3):459-64.

Abstract

Apparently normal dendrites from the frontal cortex of 7 patients with Alzheimer's disease showed mitochondria with increased density matrices and paracrystalline inclusions in the intercristal space. Most of the inclusions were formed by parallel laminae, while others presented a polyhedric arrangement. Deposits of electron-dense flocculent material were also seen. These abnormal mitochondria appeared in areas of the cortex where dendritic degeneration was more intense. These results, together with identical observations made in the cortex of patients with subacute sclerosing panencephalitis, where dendritic degeneration is also known to occur, led us to advance that mitochondrial abnormalities might precede dendritic degeneration.

摘要

7例阿尔茨海默病患者额叶皮质中看似正常的树突显示，线粒体的基质密度增加，嵴间空间存在类晶体包涵体。大多数包涵体由平行薄片形成，而其他包涵体呈多面体排列。还可见电子致密絮状物质沉积。这些异常线粒体出现在皮质中树突退变更严重的区域。这些结果，连同在亚急性硬化性全脑炎患者皮质中所做的相同观察（已知该疾病也会发生树突退变），使我们推测线粒体异常可能先于树突退变出现。