el Hachimi K H, Foncin J F
Division Montyon, Hôpital de la Salpêtrière, Paris.
C R Acad Sci III. 1990;311(11):397-402.
Neurones from five patients with Alzheimer's disease were studied semi-quantitatively on Golgi impregnated samples of cerebral cortex. They showed a dramatic reduction in dendritic spine number of pyramidal and non-pyramidal cells of all neocortical layers, as compared with control samples matched for age. Dendritic spine loss could be an initial phenomenon in Alzheimer's disease pathology.
对五名阿尔茨海默病患者的神经元进行了半定量研究，研究对象是经高尔基染色的大脑皮质样本。与年龄匹配的对照样本相比，他们发现所有新皮质层的锥体细胞和非锥体细胞的树突棘数量都显著减少。树突棘丧失可能是阿尔茨海默病病理学中的一个初始现象。
