Wang Lijun, Tian Ting
Institutes of Brain Science, Fudan University, Shanghai, China.
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Front Aging Neurosci. 2018 Jun 4;10:166. doi: 10.3389/fnagi.2018.00166. eCollection 2018.
: Subjective cognitive decline (SCD), also known as significant memory concern (SMC), has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). This study assessed the impact of gender on cognition, amyloid accumulation, the volumes of hippocampus, entorhinal cortex (EC), fusiform and medial temporal lobe (MTA) and cerebrospinal fluid (CSF) pathology biomarkers in patients reporting SMC. : Twenty-nine males (mean age ± SD: 72.3 ± 5.7 years) and 40 females (mean age ± SD: 71.0 ± 5.1 years) with SMC from the AD Neuroimaging Initiative (ADNI) were included in the study. We explored the gender discrepancies in cognition, [F] AV45 amyloid positivity, volumes of hippocampus, EC, fusiform and MTA and CSF biomarkers. : Compared with females, males showed significantly worse performance in Assessment Scale-cognitive subscale 13 (ADAS-13; = 0.004) and lower amyloid deposition ( < 0.001). However, females showed greater advantage on the task of Rey Auditory Verbal Learning Test-5 (RAVLT-5) sum ( = 0.021), RAVLT-immediate recall ( = 0.010) and reduced volumes of the hippocampus, EC, fusiform and MTA ( = 0.001, < 0.001, < 0.001, = 0.007) than males. No gender differences were found in CSF Aβ42, CSF Tau and CSF P-tau ( = 0.264, = 0.454, = 0.353). : These findings highlight that gender discrepancies should be considered in the interpretation of cognitive measures when evaluating SMC.
主观认知下降（SCD），也被称为显著记忆担忧（SMC），被认为是阿尔茨海默病（AD）在轻度认知障碍（MCI）之前的一种表现形式。本研究评估了性别对报告有SMC的患者的认知、淀粉样蛋白积累、海马体、内嗅皮质（EC）、梭状回和内侧颞叶（MTA）体积以及脑脊液（CSF）病理生物标志物的影响。：来自阿尔茨海默病神经影像倡议（ADNI）的29名患有SMC的男性（平均年龄±标准差：72.3±5.7岁）和40名女性（平均年龄±标准差：71.0±5.1岁）被纳入研究。我们探讨了认知、[F] AV45淀粉样蛋白阳性、海马体、EC、梭状回和MTA体积以及CSF生物标志物方面的性别差异。：与女性相比，男性在评估量表 - 认知子量表13（ADAS - 13； = 0.004）中的表现明显更差，且淀粉样蛋白沉积更低（ < 0.001）。然而，女性在雷伊听觉词语学习测试 - 5（RAVLT - 5）总和（ = 0.021）、RAVLT即时回忆（ = 0.010）任务上表现出更大优势，并且海马体、EC、梭状回和MTA的体积比男性更小（ = 0.001， < 0.001， < 0.001， = 0.007）。在脑脊液Aβ42、脑脊液Tau和脑脊液P - tau方面未发现性别差异（ = 0.264， = 0.454， = 0.353）。：这些发现强调，在评估SMC时解释认知测量结果时应考虑性别差异。
