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A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole.致命处方：甲氨蝶呤与复方磺胺甲恶唑联用
J Community Hosp Intern Med Perspect. 2018 Jun 12;8(3):149-151. doi: 10.1080/20009666.2018.1466598. eCollection 2018.
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Methotrexate Toxicity-Induced Pancytopenia and Mucocutaneous Ulcerations in Psoriasis.甲氨蝶呤毒性诱发银屑病患者全血细胞减少和皮肤黏膜溃疡
Cureus. 2024 Aug 5;16(8):e66222. doi: 10.7759/cureus.66222. eCollection 2024 Aug.
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Methotrexate and trimethoprim-sulphamethoxazole: extremely serious and life-threatening combination.甲氨蝶呤和甲氧苄啶-磺胺甲噁唑：极其严重且危及生命的组合。
J Clin Pharm Ther. 2013 Jun;38(3):203-5. doi: 10.1111/jcpt.12060. Epub 2013 Mar 22.
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Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole.甲氨蝶呤与甲氧苄啶-磺胺甲恶唑联合使用后发生的中毒性表皮坏死松解症。
Int J Dermatol. 2000 Aug;39(8):621-3. doi: 10.1046/j.1365-4362.2000.00022-3.x.
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[Fatal pancytopenia and methotrexate-trimethoprim-sulfamethoxazole interaction].[致命性全血细胞减少与甲氨蝶呤 - 甲氧苄啶 - 磺胺甲恶唑相互作用]
Harefuah. 2004 Jun;143(6):398-400, 464.
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Trimethoprim-sulfamethoxazole compared with ciprofloxacin for the prevention of urinary tract infection in renal transplant recipients. A double-blind, randomized controlled trial.甲氧苄啶-磺胺甲恶唑与环丙沙星预防肾移植受者尿路感染的比较。一项双盲随机对照试验。
Online J Curr Clin Trials. 1992 Aug 11;Doc No 15:[4083 words; 46 paragraphs].
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How should we manage low-dose methotrexate-induced pancytopenia in patients with rheumatoid arthritis?我们应该如何治疗类风湿关节炎患者低剂量甲氨蝶呤引起的全血细胞减少症？
Clin Rheumatol. 2018 Dec;37(12):3419-3425. doi: 10.1007/s10067-018-4242-8. Epub 2018 Jul 28.
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Therapy for the maintenance of remission in sixty-five patients with generalized Wegener's granulomatosis. Methotrexate versus trimethoprim/sulfamethoxazole.65例广泛性韦格纳肉芽肿病患者缓解期维持治疗。甲氨蝶呤与甲氧苄啶/磺胺甲恶唑对比研究。
Arthritis Rheum. 1996 Dec;39(12):2052-61. doi: 10.1002/art.1780391215.
引用本文的文献
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Impact of Prophylactic Trimethoprim-Sulfamethoxazole on Clearance of High-Dose Methotrexate in Adult Patients.预防用甲氧苄啶-磺胺甲噁唑对成人患者大剂量甲氨蝶呤清除率的影响。
JCO Oncol Pract. 2024 May;20(5):673-677. doi: 10.1200/OP.23.00792. Epub 2024 Feb 21.
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Anti-proliferative effects of the combination of Sulfamethoxazole and Quercetin via caspase3 and NFkB gene regulation: an in vitro and in vivo study.磺胺甲恶唑和槲皮素通过调控 caspase3 和 NFkB 基因的抗增殖作用：一项体内外研究。
Naunyn Schmiedebergs Arch Pharmacol. 2022 Feb;395(2):227-246. doi: 10.1007/s00210-021-02174-3. Epub 2022 Jan 7.
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The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions.类风湿关节炎的治疗前景：现状与未来方向
Front Pharmacol. 2021 May 28;12:680043. doi: 10.3389/fphar.2021.680043. eCollection 2021.
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Just the facts: Diagnosis and treatment of urinary tract infections in older adults.只讲事实：老年人尿路感染的诊断与治疗
CJEM. 2021 Sep;23(5):593-596. doi: 10.1007/s43678-021-00131-w. Epub 2021 Apr 21.
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Methotrexate and doxycycline interaction: a rare cause of pancytopenia.甲氨蝶呤与强力霉素相互作用：全血细胞减少症的罕见病因。
BMJ Case Rep. 2019 May 31;12(5):e229296. doi: 10.1136/bcr-2019-229296.
本文引用的文献
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Considerations when prescribing trimethoprim-sulfamethoxazole.开具复方磺胺甲恶唑时的注意事项。
CMAJ. 2011 Nov 8;183(16):1851-8. doi: 10.1503/cmaj.111152. Epub 2011 Oct 11.
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Adverse effects of low dose methotrexate in rheumatoid arthritis patients. A hospital-based study.低剂量甲氨蝶呤对类风湿关节炎患者的不良反应。一项基于医院的研究。
Saudi Med J. 2010 Aug;31(8):909-15.
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Canadian recommendations for use of methotrexate in patients with rheumatoid arthritis.加拿大类风湿关节炎患者甲氨蝶呤使用推荐。
J Rheumatol. 2010 Jul;37(7):1422-30. doi: 10.3899/jrheum.090978. Epub 2010 Jun 1.
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Methotrexate drug interactions in the treatment of rheumatoid arthritis: a systematic review.甲氨蝶呤治疗类风湿关节炎的药物相互作用：系统评价。
J Rheumatol. 2010 Jul;37(7):1416-21. doi: 10.3899/jrheum.090153. Epub 2010 May 1.
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Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.叶酸拮抗剂4-氨基蝶酰谷氨酸诱导儿童急性白血病的暂时缓解。
N Engl J Med. 1948 Jun 3;238(23):787-93. doi: 10.1056/NEJM194806032382301.
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Folate supplementation during methotrexate therapy for patients with psoriasis.银屑病患者甲氨蝶呤治疗期间补充叶酸。
J Am Acad Dermatol. 2005 Oct;53(4):652-9. doi: 10.1016/j.jaad.2005.06.036.
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[Fatal pancytopenia and methotrexate-trimethoprim-sulfamethoxazole interaction].[致命性全血细胞减少与甲氨蝶呤 - 甲氧苄啶 - 磺胺甲恶唑相互作用]
Harefuah. 2004 Jun;143(6):398-400, 464.
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Roy Hertz, M.D. (1909-2002): the cure of choriocarcinoma and its impact on the development of chemotherapy for cancer.罗伊·赫兹医学博士（1909 - 2002）：绒毛膜癌的治愈及其对癌症化疗发展的影响
Gynecol Oncol. 2003 May;89(2):193-8. doi: 10.1016/s0090-8258(03)00110-0.
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Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole.甲氨蝶呤与甲氧苄啶-磺胺甲恶唑联合使用后发生的中毒性表皮坏死松解症。
Int J Dermatol. 2000 Aug;39(8):621-3. doi: 10.1046/j.1365-4362.2000.00022-3.x.
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Allergic pancytopenia to trimethoprim-sulphamethoxazole for Pneumocystis carinii pneumonia following methotrexate treatment for rheumatoid arthritis.类风湿关节炎经甲氨蝶呤治疗后，因卡氏肺孢子虫肺炎使用复方磺胺甲恶唑导致过敏性全血细胞减少症。
Rheumatology (Oxford). 1999 May;38(5):475-6. doi: 10.1093/rheumatology/38.5.475.
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