新型血凝素结合硫酸寡岩藻糖及其对流感病毒感染的影响。
Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection.
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
出版信息
Chem Commun (Camb). 2018 Jul 11;54(54):7467-7470. doi: 10.1039/c8cc03865a. Epub 2018 Jun 19.
Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.
在一系列化学合成的岩藻聚糖硫酸酯衍生物（1-9）中，首次发现 5 可与流感病毒血凝素（HA）结合并抑制其血凝活性。此外，设计了一种具有 5 的三个磺酸寡岩藻糖苷部分的 C 对称三脚架配体 10，其表现出比 5 更强的血凝抑制活性。使用 MDCK 细胞的噬斑测定表明 10 可有效抑制流感病毒感染。
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