Kozak C A
J Virol. 1985 Sep;55(3):690-5. doi: 10.1128/JVI.55.3.690-695.1985.
Although xenotropic murine leukemia viruses cannot productively infect cells of laboratory mice, cells from various wild-derived mice can support replication of these viruses. Although the virus-sensitive wild mice generally lack all or most of the xenotropic proviral genes characteristic of inbred strains, susceptibility to exogenous infection is unrelated to inheritance of these sequences. Instead, susceptibility is controlled by a single dominant gene, designated Sxv, which maps to chromosome 1. Sxv is closely linked to, but distinct from Bxv-1, the major locus for induction of xenotropic murine leukemia viruses in laboratory mice. Genetic experiments designed to characterize Sxv show that this gene also controls sensitivity to a wild mouse virus with the interference properties of mink cell focus-forming murine leukemia viruses, and that Sxv-mediated susceptibility to xenotropic murine leukemia viruses is restricted by the mink cell focus-forming virus resistance gene Rmcf. These data, together with genetic mapping of the mink cell focus-forming virus cell surface receptor locus to this same region of chromosome 1, suggest that Sxv may encode a wild mouse variant of the mink cell focus-forming virus receptor that allows penetration by xenotropic murine leukemia viruses.
虽然嗜异性鼠白血病病毒不能有效地感染实验室小鼠的细胞，但来自各种野生来源小鼠的细胞能够支持这些病毒的复制。虽然对病毒敏感的野生小鼠通常缺乏近交系中嗜异性前病毒基因的全部或大部分特征，但对外源感染的易感性与这些序列的遗传无关。相反，易感性由一个单一的显性基因控制，命名为Sxv，它定位于1号染色体。Sxv与Bxv-1紧密连锁，但又与之不同，Bxv-1是实验室小鼠中诱导嗜异性鼠白血病病毒的主要基因座。旨在表征Sxv的遗传学实验表明，该基因还控制对具有水貂细胞集落形成鼠白血病病毒干扰特性的野生小鼠病毒的敏感性，并且Sxv介导的对嗜异性鼠白血病病毒的易感性受到水貂细胞集落形成病毒抗性基因Rmcf的限制。这些数据，连同水貂细胞集落形成病毒细胞表面受体基因座在1号染色体同一区域的遗传定位，表明Sxv可能编码水貂细胞集落形成病毒受体的野生小鼠变体，该变体允许嗜异性鼠白血病病毒穿透。
