Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Chemother Pharmacol. 2018 Sep;82(3):371-382. doi: 10.1007/s00280-018-3626-4. Epub 2018 Jun 18.
Lipoproteins (LPs) are a set of naturally occurring bio-nanoparticles consisting of Apo-LPs, phospholipids, a highly hydrophobic core of cholesteryl esters and triglycerides that participate mainly in the targeted transport of cholesteryl esters and other hydrophobic molecules through the bloodstream. They also are able to recognize specific receptors on normal and abnormal cells. Therefore, LPs represent a relevant tool for targeted delivery of cancer diagnostics and therapeutics due to their native biocompatibility, biodegradability, nano-scale size and receptor-mediated uptake. The circulating LPs are categorized into five classes, each with its own characteristic protein and lipid composition. Low-density LPs (LDL) and high-density LPs (HDL) are two major subclasses of LPs which were extensively subjected to attractive and versatile vehicles for targeted delivery of anticancer drugs. This study focus to highlight the potential applications of LDL and HDL bio-nanocarriers in the field of specific target drug delivery to cancer cells.
脂蛋白（LPs）是一组天然存在的生物纳米粒子，由载脂蛋白-LPs、磷脂、胆固醇酯和甘油三酯组成的高度疏水性核心组成，主要参与胆固醇酯和其他疏水分子在血液中的靶向运输。它们还能够识别正常和异常细胞上的特定受体。因此，由于其天然的生物相容性、生物降解性、纳米级尺寸和受体介导的摄取，LPs 成为癌症诊断和治疗的靶向递药的一种相关工具。循环中的 LPs 分为五类，每类都有其自身的特征性蛋白质和脂质组成。低密度脂蛋白（LDL）和高密度脂蛋白（HDL）是 LPs 的两个主要亚类，它们被广泛用作靶向递药的有吸引力和多功能载体，用于递抗癌药物。本研究重点强调 LDL 和 HDL 生物纳米载体在癌症细胞特异性靶向药物递送领域的潜在应用。
