合成脂蛋白作为纳米材料载体在靶向药物递送中的应用。
Synthetic lipoprotein as nano-material vehicle in the targeted drug delivery.
机构信息
a Active Carbohydrate Research Center, College of Chemistry , Chongqing Normal University , Chongqing , PR China.
出版信息
Drug Deliv. 2017 Dec;24(sup1):16-21. doi: 10.1080/10717544.2017.1384518.
Abstract
High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed.
摘要
高密度脂蛋白（HDL）和低密度脂蛋白（LDL）作为人体内源性脂蛋白颗粒，具有低毒性、高选择性和良好的安全性。它们可以避免被人体网状内皮系统识别和清除。这些合成脂蛋白（sLPs）作为纳米载体，已被广泛应用于肿瘤靶向药物和基因传递。本文分析和讨论了基于这两种脂质蛋白和重组脂蛋白（rLPs）作为靶向递药载体的抗癌研究进展。
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