神经退行性疾病中的RNA降解
RNA Degradation in Neurodegenerative Disease.
作者信息
Weskamp Kaitlin, Barmada Sami J
机构信息
Neuroscience Graduate Program and Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
出版信息
Adv Neurobiol. 2018;20:103-142. doi: 10.1007/978-3-319-89689-2_5.
Abstract
Ribonucleic acid (RNA) homeostasis is dynamically modulated in response to changing physiological conditions. Tight regulation of RNA abundance through both transcription and degradation determines the amount, timing, and location of protein translation. This balance is of particular importance in neurons, which are among the most metabolically active and morphologically complex cells in the body. As a result, any disruptions in RNA degradation can have dramatic consequences for neuronal health. In this chapter, we will first discuss mechanisms of RNA stabilization and decay. We will then explore how the disruption of these pathways can lead to neurodegenerative disease.
摘要
核糖核酸（RNA）稳态会根据不断变化的生理状况进行动态调节。通过转录和降解对RNA丰度进行严格调控，决定了蛋白质翻译的数量、时间和位置。这种平衡在神经元中尤为重要，神经元是体内代谢最活跃、形态最复杂的细胞之一。因此，RNA降解过程中的任何干扰都可能对神经元健康产生重大影响。在本章中，我们将首先讨论RNA稳定和降解的机制。然后，我们将探讨这些途径的破坏如何导致神经退行性疾病。
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本文引用的文献
1
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Neuron. 2017 Sep 13;95(6):1292-1305.e5. doi: 10.1016/j.neuron.2017.08.039.
2
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.肌萎缩侧索硬化症和额颞叶痴呆中的TIA1突变促进相分离并改变应激颗粒动力学。
Neuron. 2017 Aug 16;95(4):808-816.e9. doi: 10.1016/j.neuron.2017.07.025.
3
Myotonic dystrophy: candidate small molecule therapeutics.肌强直性营养不良：候选小分子治疗药物。
Drug Discov Today. 2017 Nov;22(11):1740-1748. doi: 10.1016/j.drudis.2017.07.011. Epub 2017 Aug 2.
4
C9orf72 expansion disrupts ATM-mediated chromosomal break repair.C9orf72基因扩增破坏了ATM介导的染色体断裂修复。
Nat Neurosci. 2017 Sep;20(9):1225-1235. doi: 10.1038/nn.4604. Epub 2017 Jul 17.
5
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J Mol Biol. 2017 Nov 10;429(22):3500-3524. doi: 10.1016/j.jmb.2017.05.027. Epub 2017 Jun 3.
6
Quantitative analysis of cryptic splicing associated with TDP-43 depletion.与TDP-43缺失相关的隐蔽剪接的定量分析。
BMC Med Genomics. 2017 May 26;10(1):38. doi: 10.1186/s12920-017-0274-1.
7
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8
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9
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Neurobiol Aging. 2017 Jun;54:214.e1-214.e6. doi: 10.1016/j.neurobiolaging.2017.02.008. Epub 2017 Feb 20.
10
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Mol Neurodegener. 2017 Feb 2;12(1):13. doi: 10.1186/s13024-016-0144-x.
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