Dienstag J L, Werner B G, McLane M F, Snydman D R, Grady G F, Craven D E, Crumpacker C S, Polk B F, Platt R, Allan J
JAMA. 1985;254(8):1064-6.
A proportion of the plasma for the triply inactivated, plasma-derived hepatitis B vaccine produced in the United States is obtained from homosexual men. Because homosexual men are a high-risk group for the acquired immunodeficiency syndrome (AIDS), concern has emerged that the vaccine could harbor the AIDS agent. To evaluate this risk, we tested 15-month postvaccination serum samples for antibodies to human T-cell lymphotropic virus type III in 100 health care workers who had received inactivated hepatitis B vaccine lots made from plasma collected between 1977 and 1979 and 100 who had received placebo injections. None of the 200 health workers had serological evidence of human T-cell lymphotropic virus type III infection. These serological findings lend additional support to earlier epidemiologic and immunologic observations suggesting that hepatitis B vaccine does not transmit infection with an AIDS virus.
美国生产的三倍灭活血浆源性乙肝疫苗有一部分血浆取自男同性恋者。由于男同性恋者是获得性免疫缺陷综合征（艾滋病）的高危人群，因此有人担心该疫苗可能携带艾滋病病原体。为评估这种风险，我们对100名接种疫苗15个月后的医护人员的血清样本进行检测，这些人员中，100人接种的是1977年至1979年间采集的血浆制成的灭活乙肝疫苗，另外100人接受的是安慰剂注射，检测他们血清中抗人类T细胞嗜淋巴细胞病毒III型抗体。200名医护人员中无人有感染人类T细胞嗜淋巴细胞病毒III型的血清学证据。这些血清学结果为早期的流行病学和免疫学观察提供了更多支持，表明乙肝疫苗不会传播艾滋病病毒感染。
