Cash R, Lasbennes F, Sercombe R, Seylaz J, Agid Y
Life Sci. 1985 Aug 12;37(6):531-6. doi: 10.1016/0024-3205(85)90465-5.
The binding of adrenergic ligands (3H-prazosin, 3H-clonidine, 3H-dihydroalprenolol) was studied on a preparation of cerebral microvessels in the prefrontal cortex and putamen of control and Parkinsonian subjects. The adrenergic receptor density in microvessels of control patients was less than 0.5% and 3.3% respectively of the total binding. A significant decrease in the number of alpha-1 binding sites was observed on microvessels in the putamen of patients with Parkinson's disease.
在对照组和帕金森病患者的前额叶皮质和壳核脑微血管制剂上研究了肾上腺素能配体（3H-哌唑嗪、3H-可乐定、3H-二氢阿普洛尔）的结合情况。对照组患者微血管中的肾上腺素能受体密度分别小于总结合量的0.5%和3.3%。在帕金森病患者壳核的微血管上观察到α-1结合位点数量显著减少。
