Diop L, Brière R, Grondin L, Reader T A
Brain Res. 1987 Feb 3;402(2):403-8. doi: 10.1016/0006-8993(87)90055-2.
The tritiated adrenergic antagonists [3H]dihydroalprenolol ([3H]DHA; beta-receptors), [3H]prazosin ([3H]PRZ; alpha 1-receptors), and [3H]idazoxan ([3H]IDA; alpha 2-receptors) were used to determine the distribution of these sites in 5 defined areas of the adult rat cerebral cortex. The highest density of [3H]PRZ binding was found in the prefrontal cortex, with a lower and homogeneous distribution for the frontal, parietal, occipital and temporal areas. The [3H]IDA binding sites were fairly uniform for all areas, except for the temporal cortex where it was very dense. In contrast, beta-adrenoceptors labelled by [3H]DHA were very homogeneous for all the regions examined. The functional significance of the distribution of alpha 1, alpha 2 and beta-adrenoceptors is discussed in relation to the catecholamine innervation and monoamine contents measured by high performance liquid chromatography.
用氚标记的肾上腺素能拮抗剂[3H]二氢心得舒（[3H]DHA；β受体）、[3H]哌唑嗪（[3H]PRZ；α1受体）和[3H]咪唑克生（[3H]IDA；α2受体）来确定这些位点在成年大鼠大脑皮层5个特定区域的分布。发现[3H]PRZ结合的最高密度出现在前额叶皮层，而额叶、顶叶、枕叶和颞叶区域的分布较低且均匀。除颞叶皮层[3H]IDA结合位点非常密集外，所有区域的[3H]IDA结合位点相当均匀。相比之下，[3H]DHA标记的β肾上腺素受体在所有检测区域都非常均匀。结合通过高效液相色谱法测定的儿茶酚胺神经支配和单胺含量，讨论了α1、α2和β肾上腺素受体分布的功能意义。
