血浆催产素个体间变异与剖宫产切口痛的关系。
Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain.
机构信息
From the Department of Anesthesiology, Perioperative and Pain Medicine.
Women's Pain Group, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
出版信息
Anesth Analg. 2019 Oct;129(4):e118-e121. doi: 10.1213/ANE.0000000000003567.
Oxytocin has known antinociceptive effects and is upregulated perinatally. This pilot study investigated the association of plasma oxytocin and postcesarean incisional pain. Plasma samples from 18 patients undergoing elective cesarean delivery were drawn at 1 hour preoperatively and 1 and 24 hours postoperatively and analyzed by using enzyme-linked immunosorbent assay. Pain was assessed at 1 day, 8 weeks, 3 months, and 6 months postoperatively. Incisional pain at 24 hours was inversely correlated with 1- and 24-hour oxytocin levels, with higher plasma oxytocin associated with lower pain (ρ, -0.52 and -0.66; P < .05).
催产素具有已知的镇痛作用，并在围产期上调。这项初步研究调查了血浆催产素与剖宫产切口疼痛之间的关系。从 18 名接受择期剖宫产的患者中抽取血浆样本，分别于术前 1 小时、术后 1 小时和 24 小时采集，并通过酶联免疫吸附试验进行分析。术后 1 天、8 周、3 个月和 6 个月进行疼痛评估。术后 24 小时切口疼痛与 1 小时和 24 小时催产素水平呈负相关，较高的血浆催产素与较低的疼痛相关（ρ，-0.52 和-0.66；P <.05）。
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