Alén M, Reinilä M, Vihko R
Med Sci Sports Exerc. 1985 Jun;17(3):354-9.
Endocrine effects of self-administration of high doses of anabolic steroids and testosterone were investigated in five power athletes during 26 wk of training, and for the following 12-16 wk after drug withdrawal. After 26 wk of anabolic steroid and testosterone administration, serum testosterone concentrations had increased 2.3-fold. This was associated with increased concentrations of serum estradiol, which rose 7-fold to values (0.48 nmol X 1(-1) typical for females. There was a major decrease in serum FSH and LH concentrations, but they returned to control levels following drug withdrawal. However, serum testosterone concentrations stayed at low levels (9 nmol X 1(-1) ) during this follow-up period, indicating long-lasting impairment of testicular endocrine function. Serum ACTH concentrations were also decreased during steroid administration, possibly due to a corticoid-like effect of some of the anabolic steroids taken in high doses. However, no changes were seen in serum cortisol. The only consistent change in the control group was an increase in serum LH concentrations during the most intensive training, suggesting that a decreasing tendency of serum testosterone was compensated for by augmented LH secretion.
在26周的训练期间，对五名力量型运动员自我服用高剂量合成代谢类固醇和睾酮的内分泌效应进行了研究，并在停药后的接下来12 - 16周进行了观察。在服用合成代谢类固醇和睾酮26周后，血清睾酮浓度增加了2.3倍。这与血清雌二醇浓度升高有关，雌二醇浓度上升了7倍，达到女性典型的浓度值（0.48 nmol·L⁻¹）。血清促卵泡生成素（FSH）和促黄体生成素（LH）浓度大幅下降，但停药后恢复到对照水平。然而，在这个随访期间，血清睾酮浓度一直维持在低水平（9 nmol·L⁻¹），表明睾丸内分泌功能受到长期损害。在服用类固醇期间，血清促肾上腺皮质激素（ACTH）浓度也下降，这可能是由于高剂量服用的一些合成代谢类固醇具有类皮质激素效应。然而，血清皮质醇未见变化。对照组唯一一致的变化是在训练最密集期间血清LH浓度增加，这表明血清睾酮的下降趋势通过增加LH分泌得到了补偿。
