García-Pascual I J, Rozán Flores M A
Sección de Planificación Familiar y Fertilidad, Centro Médico San José de Tiabaya, Arequipa, Peru.
Rev Clin Esp. 1996 Mar;196(3):167-70.
The effect of desmopressin (DDAVP) administration (2.5 micrograms/12 hours) on serum concentrations of FSH, LH and testosterone was studied in six men. No significant changes were observed in serum concentrations of FSH and LH after 9 days with DDAVP therapy. Nevertheless, serum concentrations of testosterone after 12 hours of DDAVP administration were significantly higher than basal concentrations. Three hours after the administration of DDAVP, serum testosterone concentrations decreased significantly. The conclusion reached was that low doses of desmopressin do not change serum concentrations of FSH and LH, but serum concentration of testosterone is decreased within three hours after the administration, although an increase is observed 12 hours later possibly due to a "rebound effect". Desmopressin would therefore directly act upon human testicle.
在六名男性中研究了去氨加压素（DDAVP）（2.5微克/12小时）给药对血清促卵泡激素（FSH）、促黄体生成素（LH）和睾酮浓度的影响。接受DDAVP治疗9天后，血清FSH和LH浓度未观察到显著变化。然而，给予DDAVP 12小时后血清睾酮浓度显著高于基础浓度。给予DDAVP三小时后，血清睾酮浓度显著下降。得出的结论是，低剂量去氨加压素不会改变血清FSH和LH浓度，但给药后三小时内血清睾酮浓度会降低，尽管12小时后观察到升高，这可能是由于“反弹效应”。因此，去氨加压素会直接作用于人类睾丸。
