神经生长因子增强Ia感觉神经元的中枢突触功能。

Nerve growth factor enhances central synaptic function of Ia sensory neurons.

作者信息

Kuno M, Miyata Y, Homma S, Ogawa M

出版信息

Neurosci Res. 1985 Apr;2(4):275-80. doi: 10.1016/0168-0102(85)90005-7.

Abstract

Daily treatment of neonatal rats with nerve growth factor (NGF) significantly enhanced monosynaptic excitatory postsynaptic potentials (EPSPs) evoked in spinal motoneurons by muscle afferent volleys. A few weeks after crush of a muscle nerve, the EPSPs elicited by afferent volleys from the muscle nerve were markedly depressed. This synaptic depression could be partly prevented by daily application of NGF. It is concluded that central synaptic function of Ia sensory neurons is responsive to exogenous NGF in postnatal animals.

摘要

每日用神经生长因子（NGF）处理新生大鼠，可显著增强肌肉传入冲动在脊髓运动神经元中诱发的单突触兴奋性突触后电位（EPSP）。肌肉神经挤压几周后，肌肉神经传入冲动所引发的EPSP明显降低。每日应用NGF可部分预防这种突触抑制。由此得出结论，在出生后的动物中，Ia感觉神经元的中枢突触功能对外源性NGF有反应。