Cuciureanu Magdalena D., Vink Robert
Department of Pharmacology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, 700115, Romania.
Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, South Australia 5005, Australia.
Magnesium status is highly associated with stress levels, with both stress and hypomagnesemia potentiating each other’s negative effects. Indeed, hypomagnesemia has been associated with stressful conditions such as photosensitive headache, fibromyalgia, chronic fatigue syndrome, audiogenic stress, cold stress, and physical stress, amongst others. The role of magnesium in these conditions is unclear, although a number of potential mechanisms for magnesium’s action have been identified including via the glutamatergic, serotonergic, and adrenergic neurotransmitter systems, as well as via several neuro- hormones. The current review examines the link between magnesium deficiency and stress, focusing on the association between magnesium and various stress pathologies, magnesium’s potential interaction with stress pathways, and magnesium’s effects on the brain.
镁状态与应激水平高度相关，应激和低镁血症会相互增强彼此的负面影响。事实上，低镁血症与多种应激状况有关，如光敏性头痛、纤维肌痛、慢性疲劳综合征、声源性应激、冷应激和身体应激等。镁在这些状况中的作用尚不清楚，不过已经确定了镁发挥作用的一些潜在机制，包括通过谷氨酸能、血清素能和肾上腺素能神经递质系统，以及通过多种神经激素。本综述探讨了镁缺乏与应激之间的联系，重点关注镁与各种应激相关病症的关联、镁与应激通路的潜在相互作用，以及镁对大脑的影响。
