Sagar Accha Nandini, Kalburgi Vishal, Vagha Jayant D, Taksande Amar, Meshram Revat J, Lohiya Sham
Department of Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Aug 11;16(8):e66643. doi: 10.7759/cureus.66643. eCollection 2024 Aug.
Magnesium is an essential mineral with pivotal roles in various physiological processes, including enzyme function, neuromuscular regulation, and cardiovascular health. Magnesium's importance in critically ill pediatric patients is magnified due to its involvement in maintaining cellular homeostasis and potential therapeutic benefits. This review comprehensively analyzes magnesium's role in critical care pediatrics, focusing on its physiological mechanisms, clinical impact, and therapeutic strategies. Magnesium's functions in energy production, protein synthesis, and electrolyte balance underscore its significance in critical illness, where imbalances can lead to severe complications such as arrhythmias, neuromuscular disturbances, and respiratory issues. The review examines the clinical consequences of magnesium deficiency, including its impact on various body systems and the potential exacerbation of critical conditions. It also explores therapeutic strategies to optimize patient care, including supplementation practices, dosing considerations, and monitoring protocols. By summarizing recent research and clinical guidelines, this review aims to enhance understanding of magnesium's role in critical care and provide evidence-based recommendations for its management. The insights provided are intended to guide clinicians in integrating magnesium therapy into critical care practices, ultimately improving patient outcomes and advancing the management of critically ill pediatric patients.
镁是一种必需矿物质，在各种生理过程中发挥着关键作用，包括酶功能、神经肌肉调节和心血管健康。由于镁参与维持细胞内环境稳定并具有潜在治疗益处，其在危重症儿科患者中的重要性更加凸显。本综述全面分析了镁在儿科重症监护中的作用，重点关注其生理机制、临床影响和治疗策略。镁在能量产生、蛋白质合成和电解质平衡中的功能突出了其在危重症中的重要性，在危重症中，失衡可能导致严重并发症，如心律失常、神经肌肉紊乱和呼吸问题。该综述研究了镁缺乏的临床后果，包括其对身体各个系统的影响以及危重症的潜在加重情况。它还探讨了优化患者护理的治疗策略，包括补充方法、剂量考量和监测方案。通过总结近期研究和临床指南，本综述旨在增进对镁在重症监护中作用的理解，并为其管理提供循证建议。所提供的见解旨在指导临床医生将镁治疗纳入重症监护实践，最终改善患者预后并推进危重症儿科患者的管理。
