Yablon Lisa A., Mauskop Alexander
The New York Headache Center, 30 East 76th Street, New York, NY 10021, USA.
Magnesium's role in migraine pathogenesis is well-described, with deficiencies known to promote cortical spreading depression, alter nociceptive processing and neurotransmitter release, and encourage the hyperaggregation of platelets, all major elements of migraine development. Research on magnesium has found it to be a potentially well-tolerated, safe and inexpensive option for migraine prevention, while it may also be effective as an acute treatment option for headaches including migraines, tension- type headaches and cluster headaches, particularly in certain patient subsets. This chapter will review the various aspects of migraine in which magnesium plays a part, as well as numerous studies on the use of magnesium in both headache prophylaxis and in the acute treatment of headaches, offering recommendations in its use in clinical practice.
镁在偏头痛发病机制中的作用已得到充分描述，已知镁缺乏会促进皮层扩散性抑制，改变伤害性信息处理和神经递质释放，并促使血小板过度聚集，这些都是偏头痛发展的主要因素。对镁的研究发现，它是一种潜在耐受性良好、安全且廉价的偏头痛预防选择，同时它也可能作为包括偏头痛、紧张型头痛和丛集性头痛在内的头痛急性治疗选择有效，特别是在某些患者亚组中。本章将回顾镁在偏头痛中起作用的各个方面，以及关于镁在头痛预防和头痛急性治疗中的大量研究，并就其在临床实践中的应用提供建议。
