单核苷酸多态性 rs6720173（ABCG5）、rs3808607（CYP7A1）和 rs760241（DHCR7）的组合与乳制品摄入对血清胆固醇的不同反应有关。
The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption.
机构信息
a Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
b Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.
出版信息
Appl Physiol Nutr Metab. 2018 Oct;43(10):1090-1093. doi: 10.1139/apnm-2018-0085. Epub 2018 Jun 19.
Existing evidence on the influence of genetic architecture on serum cholesterol responsiveness to dietary interventions focuses on individual single nucleotide polymorphisms and single nutrients. We associated the combination of ABCG5 rs6720173-C, CYP7A1 rs3808607-TT, and DHCR7 rs760241-GG genotypes with lower low-density lipoprotein cholesterol concentrations relative to the combination of rs6720173-GG, rs3808607-G, and rs760241-A genotypes (-0.37 ± 0.12 (n = 9) vs. +0.38 ± 0.14 mmol/L (n = 7), p = 0.0016) following a blended dairy (3 servings/day for 4 weeks) intervention.
现有证据表明，遗传结构对饮食干预下血清胆固醇反应的影响主要集中在单个单核苷酸多态性和单一营养素上。我们将 ABCG5 rs6720173-C、CYP7A1 rs3808607-TT 和 DHCR7 rs760241-GG 基因型的组合与 rs6720173-GG、rs3808607-G 和 rs760241-A 基因型的组合进行了比较，发现前者的低密度脂蛋白胆固醇浓度更低（-0.37 ± 0.12 [n = 9] 比 +0.38 ± 0.14 mmol/L [n = 7]，p = 0.0016），这种差异是在摄入混合乳制品（每天 3 份，持续 4 周）干预后的结果。
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