Department of Pharmaceutics and Drug Delivery, The University of Mississippi, Mississippi 38677.
Materials Modification Inc., Fairfax, Virginia 22031.
J Pharm Sci. 2018 Oct;107(10):2628-2634. doi: 10.1016/j.xphs.2018.06.005. Epub 2018 Jun 18.
Second-degree burn injury is the most common type of burn injury, which usually takes 2-3 weeks for complete healing. However, such patients suffer with intense pain associated with development of hyperalgesia and allodynia. Here, we prepare a silver clay patch using montmorillonite clay, betaine, and silver nitrate. Later, the silver clay patches were loaded with fentanyl. Furthermore, the patches were fabricated into burn wound dressings. The dressings were first subjected to ex vivo skin penetration studies and were later evaluated for thermal hyperalgesia and mechanical allodynia using second-degree burn injury rodent model. Our results show that application of fentanyl-loaded dermal clay (FLDC) dressings for 3 h showed significant increase of paw withdrawal latency (p <0.001) against hyperalgesia starting from 30 min after removal of patch to up to 6 h. Similarly, the FLDC dressings also potentiated the paw withdrawal threshold for up to 4 h after application (p <0.001). From these studies, we can conclude that FLDC dressings are ideal topical formulations for better management of pain in second-degree burns.
二度烧伤是最常见的烧伤类型，通常需要 2-3 周才能完全愈合。然而，此类患者会伴有剧烈疼痛，并伴有痛觉过敏和感觉异常。在这里，我们使用蒙脱石粘土、甜菜碱和硝酸银制备了一种银粘土贴片。随后，将银粘土贴片加载芬太尼。此外，还将贴片制成烧伤创面敷料。首先对这些敷料进行离体皮肤渗透研究，然后使用二度烧伤啮齿动物模型评估其对热痛觉过敏和机械性感觉异常的作用。研究结果表明，应用芬太尼负载的皮肤粘土（FLDC）敷料 3 小时后，从去除贴片后 30 分钟开始，至 6 小时，对痛觉过敏的足部退缩潜伏期显著增加（p<0.001）。同样，FLDC 敷料在应用后 4 小时内也能增强足部退缩阈值（p<0.001）。从这些研究中，我们可以得出结论，FLDC 敷料是治疗二度烧伤疼痛的理想局部制剂。
