Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
The Tisch Family Zoological Gardens in Jerusalem, Box 898, Manhat, Jerusalem 91008, Israel.
Dev Cell. 2018 Jun 18;45(6):726-737.e3. doi: 10.1016/j.devcel.2018.05.024.
Developmental processes in different mammals are thought to share fundamental cellular mechanisms. We report a dramatic increase in cell size during postnatal pancreas development in rodents, accounting for much of the increase in organ size after birth. Hypertrophy of pancreatic acinar cells involves both higher ploidy and increased biosynthesis per genome copy; is maximal adjacent to islets, suggesting endocrine to exocrine communication; and is partly driven by weaning-related processes. In contrast to the situation in rodents, pancreas cell size in humans remains stable postnatally, indicating organ growth by pure hyperplasia. Pancreatic acinar cell volume varies 9-fold among 24 mammalian species analyzed, and shows a striking inverse correlation with organismal lifespan. We hypothesize that cellular hypertrophy is a strategy for rapid postnatal tissue growth, entailing life-long detrimental effects.
不同哺乳动物的发育过程被认为共享基本的细胞机制。我们报告了啮齿动物出生后胰腺发育过程中细胞大小的显著增加，这解释了出生后器官大小增加的大部分原因。胰腺腺泡细胞的肥大既涉及更高的倍性，也涉及每个基因组拷贝的生物合成增加；在胰岛附近达到最大值，表明内分泌与外分泌的通讯；并且部分受到断奶相关过程的驱动。与啮齿动物的情况相反，人类出生后胰腺细胞大小保持稳定，表明通过纯增生来实现器官生长。在分析的 24 种哺乳动物中，胰腺腺泡细胞体积变化了 9 倍，与生物体寿命呈惊人的反比关系。我们假设细胞肥大是一种快速的出生后组织生长策略，需要终生的不利影响。
