鸟枪弹样视网膜脉络膜炎2年期间的脉络膜厚度

Choroidal Thickness in Birdshot Retinochoroiditis Over a 2-Year Period.

作者信息

Forte Raimondo, Aptel Florent, Thia-Soui-Tchong Kim, Salmon Lenore, Mailhac Adriane, Bouillet Laurence, Chiquet Christophe

机构信息

Department of Ophthalmology, University Hospital (Centre Hospitalier Universitaire Grenoble-Alpes), Grenoble-Alpes University, Grenoble, France.

Department of Internal Medicine, University Hospital (Centre Hospitalier Universitaire Grenoble-Alpes), Grenoble-Alpes University, Grenoble, France.

出版信息

Ophthalmologica. 2019;241(1):49-55. doi: 10.1159/000485665. Epub 2018 Jun 19.

DOI:10.1159/000485665

PMID:29920484

Abstract

PURPOSE

To evaluate 2-year choroidal changes in eyes with birdshot retinochoroiditis (BRC).

METHODS

Thirteen patients (26 eyes) with BRC were prospectively evaluated during a 2-year period with standard automated perimetry (SAP), fluorescein angiography, indocyanine green angiography and optical coherence tomography (Spectralis Heidelberg Retinal Angiograph + optical coherence tomography). Enhanced-depth imaging optical coherence tomography was performed.

RESULTS

Eight patients (61%) were females; the patients mean age was 60 ± 4.7 (range 49-66) years. At baseline, best-corrected visual acuity (BCVA) was 0.08 ± 0.2 and foveal sensitivity threshold (FST) at SAP was 34.04 ± 2.6; at 2-year visit, no significant changes were observed (BCVA 0.06 ± 02, p = 0.1 and FST 34.36 ± 2.6, p = 0.1). In all cases, at the 2-year visit, a significant reduction of choroidal thickness was present only at the fovea (p = 0.01). The rate of foveal choroidal thinning was 1.8 ± 1.6 µm per month. When compared to baseline, suprachoroidal fluid (SCF) was more frequent (42.3 vs. 23%; p = 0.002). The amount of foveal choroidal thinning was associated with the presence of SCF at baseline (p = 0.005).

CONCLUSION

In patients with BRC, foveal choroidal thinning and increase of SCF at 2-year follow-up can be observed, even in the absence of visual loss.

摘要

目的

评估鸟枪弹样视网膜脉络膜炎（BRC）患者2年的脉络膜变化。

方法

对13例（26只眼）BRC患者进行为期2年的前瞻性评估，采用标准自动视野计（SAP）、荧光素血管造影、吲哚菁绿血管造影和光学相干断层扫描（海德堡视网膜血管造影仪+光学相干断层扫描）。进行了增强深度成像光学相干断层扫描。

结果

8例（61%）为女性；患者平均年龄为60±4.7（范围49 - 66）岁。基线时，最佳矫正视力（BCVA）为0.08±0.2，SAP检查时黄斑中心凹敏感度阈值（FST）为34.04±2.6；在2年随访时，未观察到显著变化（BCVA 0.06±0.2，p = 0.1；FST 34.36±2.6，p = 0.1）。在所有病例中，2年随访时，仅黄斑中心凹处脉络膜厚度显著降低（p = 0.01）。黄斑中心凹脉络膜变薄速率为每月1.8±1.6 µm。与基线相比，脉络膜上腔积液（SCF）更常见（42.3%对23%；p = 0.002）。黄斑中心凹脉络膜变薄程度与基线时SCF的存在相关（p = 0.005）。