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CXCR7 在弥漫性大 B 细胞淋巴瘤中的表达将 CXCR4+患者分为预后较好的亚组。

CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis.

机构信息

Biomedical Research Institute Sant Pau (IIB-Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

CIBER en Bioingeniería, Biomateriales y Nanomecidicina (CIBER-BBN), Barcelona, Spain.

出版信息

PLoS One. 2018 Jun 19;13(6):e0198789. doi: 10.1371/journal.pone.0198789. eCollection 2018.

DOI:10.1371/journal.pone.0198789
PMID:29920526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6007902/
Abstract

The CXCR4/CXCL12 axis has been extensively associated with different types of cancer correlating with higher aggressiveness and metastasis. In diffuse large B-cell lymphoma (DLBCL), the expression of the chemokine receptor CXCR4 is involved in the dissemination of malignant B cells and is a marker of poor prognosis. CXCR7 is a chemokine receptor that binds to the same ligand as CXCR4 and regulates de CXCR4-CXCL12 axis. These findings together with the report of CXCR7 prognostic value in several tumor types, led us to evaluate the expression of CXCR7 in diffuse large B-cell lymphoma biopsies. Here, we describe that CXCR7 receptor is an independent prognostic factor that associates with good clinical outcome. Moreover, the expression of CXCR7 associates with increased survival in CXCR4+ but not in CXCR4- DLBCL patients. Thus, the combined immunohistochemical evaluation of both CXCR7 and CXCR4 expression in DLBCL biopsies may improve their prognostic value as single markers. Finally, we show that CXCR7 overexpression in vitro is able to diminish DLBCL cell survival and increase their sensitivity to antitumor drugs. Hence, further studies on the CXCR7 receptor may establish its role in DLBCL and the molecular mechanisms that modulate CXCR4 activity.

摘要

CXCR4/CXCL12 轴与不同类型的癌症广泛相关，与更高的侵袭性和转移相关。在弥漫性大 B 细胞淋巴瘤 (DLBCL) 中，趋化因子受体 CXCR4 的表达参与恶性 B 细胞的扩散，是预后不良的标志物。CXCR7 是一种趋化因子受体，与 CXCR4 结合相同的配体，并调节 CXCR4-CXCL12 轴。这些发现以及 CXCR7 在几种肿瘤类型中的预后价值的报告，促使我们评估 CXCR7 在弥漫性大 B 细胞淋巴瘤活检中的表达。在这里，我们描述了 CXCR7 受体是一个独立的预后因素，与良好的临床结果相关。此外，CXCR7 的表达与 CXCR4+但不是 CXCR4-DLBCL 患者的生存率增加相关。因此，在 DLBCL 活检中联合免疫组织化学评估 CXCR7 和 CXCR4 的表达可能会提高其作为单一标志物的预后价值。最后，我们表明 CXCR7 在体外的过表达能够降低 DLBCL 细胞的存活率并增加它们对抗肿瘤药物的敏感性。因此，对 CXCR7 受体的进一步研究可能会确定其在 DLBCL 中的作用以及调节 CXCR4 活性的分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/1421baf5bc92/pone.0198789.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/d32b1740eca0/pone.0198789.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/da097c22187d/pone.0198789.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/9208393464d6/pone.0198789.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/1421baf5bc92/pone.0198789.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/d32b1740eca0/pone.0198789.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/da097c22187d/pone.0198789.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/9208393464d6/pone.0198789.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b20/6007902/1421baf5bc92/pone.0198789.g004.jpg

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