Department of Molecular and Cellular Biology, University of California-Davis, Davis, CA, United States of America.
Departamento de Química, Universidade Federal do Paraná, Laboratório de Ecologia Química e Síntese Orgânica, Curitiba-PR, Brazil.
PLoS One. 2018 Jun 19;13(6):e0199386. doi: 10.1371/journal.pone.0199386. eCollection 2018.
Insect repellents are widely used to fend off nuisance mosquitoes and, more importantly, to reduce or eliminate mosquito bites in areas where viruses and other vector-borne diseases are circulating. Synthesized more than six decades ago, DEET is the most widely used insect repellent. Plant-derived compounds are used in a plethora of commercial formulations and natural recipes to repel mosquitoes. They are also used as fragrances. We analysed Bombshell® to identify the constituent(s) eliciting a previously reported "off- label" repellence activity. The two major fragrance ingredients in Bombshell, i.e., methyl dihydrojasmonate and lilial, demonstrated strong repellence against the southern house mosquito, Culex quinquefasciatus, in laboratory assays. Both compounds activated a previously identified DEET-sensitive odorant receptor, CquiOR136. These compounds were also major constituents of Ivanka Trump eau de parfum. The methyl dihydrojasmonate content was higher in the Ivanka Trump perfume than in Bombshell, the reverse being true for lilial. Both Bombshell and Ivanka Trump eaux de parfums retained activity for as long as 6 hours in laboratory assays. Although wearing these perfumes may repel nuisance mosquitoes, their use as "off-label" repellents against infected mosquitoes is not recommended.
驱虫剂被广泛用于驱赶讨厌的蚊子，更重要的是，在病毒和其他媒介传播疾病流行的地区，减少或消除蚊子叮咬。合成于六十多年前的避蚊胺是最广泛使用的驱虫剂。植物衍生的化合物被用于大量的商业配方和天然配方中，以驱除蚊子。它们也被用作香料。我们分析了 Bombshell®，以确定引起先前报道的“标签外”驱避活性的成分。Bombshell 中的两种主要香料成分，即甲基二氢茉莉酮酸甲酯和戊基肉桂醛，在实验室试验中对南方家蚊 Culex quinquefasciatus 表现出强烈的驱避作用。这两种化合物都激活了先前鉴定的 DEET 敏感气味受体 CquiOR136。这两种化合物也是 Ivanka Trump 淡香精的主要成分。甲基二氢茉莉酮酸甲酯在 Ivanka Trump 香水中的含量高于 Bombshell，而戊基肉桂醛则相反。Bombshell 和 Ivanka Trump 淡香精在实验室试验中保持长达 6 小时的活性。尽管这些香水可能会驱赶讨厌的蚊子，但不建议将其用作针对受感染蚊子的“标签外”驱避剂。
