Ghielmetti Vivien, Wichert Brigitta, Rüegg Simon, Frey Diana, Liesegang Annette
Vetsuisse Faculty, Institute of Animal Nutrition, University of Zurich, Zurich, Switzerland.
Vetsuisse Faculty, Section of Veterinary Epidemiology, University of Zurich, Zurich, Switzerland.
J Anim Physiol Anim Nutr (Berl). 2018 Oct;102(5):1401-1410. doi: 10.1111/jpn.12928. Epub 2018 Jun 19.
Overweight and obesity are multifactorial diseases caused by an imbalance in energy metabolism. An underlying genetic predisposition is often a factor in these conditions. In the cat breeding family of the Institute of Animal Nutrition at the Vetsuisse Faculty, University of Zurich, a segregating overweight phenotype with a genetic contribution was observed. From this breeding family, 26 kittens were followed from birth up to 8 months of age. During this time, food intake was measured using an automatic feeding station, and energy expenditure was investigated using indirect calorimetry at the ages of 4 and 6 months. Dual-energy X-ray absorptiometry (DEXA) was performed and blood glucose, leptin and insulin were measured at the ages of 4, 6 and 8 months. The kittens were also weighed daily for the first 2 weeks of life, every second day until weaning and once per week until 8 months of age. The body condition score (BCS) was evaluated monthly between 2 and 8 months of age. The main finding of this study is that a predisposition to overweight is connected to a higher food intake early in life, with no significant alterations in energy expenditure. The leptin blood levels were related to body fat percentage, and insulin sensitivity did not seem to be affected.
超重和肥胖是由能量代谢失衡引起的多因素疾病。潜在的遗传易感性通常是这些病症的一个因素。在苏黎世大学兽医学院动物营养研究所的猫繁育群体中，观察到一种具有遗传因素的分离性超重表型。从这个繁育群体中，选取了26只小猫，从出生一直跟踪到8个月大。在此期间，使用自动喂食站测量食物摄入量，并在4个月和6个月大时使用间接测热法研究能量消耗。在4个月、6个月和8个月大时进行双能X线吸收法（DEXA）检测，并测量血糖、瘦素和胰岛素水平。小猫在出生后的前2周每天称重，断奶前每隔一天称重一次，直到8个月大每周称重一次。在2至8个月大期间每月评估身体状况评分（BCS）。这项研究的主要发现是，超重倾向与生命早期较高的食物摄入量有关，而能量消耗没有显著变化。瘦素血液水平与体脂百分比相关，胰岛素敏感性似乎未受影响。
