单纯性白内障超声乳化术后意外过量使用拉坦前列素导致的黄斑囊样水肿

Cystoid Macular Edema Due to Accidental Latanoprost Overdose After Uncomplicated Phacoemulsification.

作者信息

Makri Olga E, Tsekouras Iasonas K, Plotas Panagiotis, Tsapardoni Foteini, Pallikari Athina, Georgakopoulos Constantine D

机构信息

Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.

出版信息

Curr Drug Saf. 2018;13(3):208-210. doi: 10.2174/1574886313666180619163845.

DOI:10.2174/1574886313666180619163845

PMID:29921209

Abstract

OBJECTIVE

We present an interesting case of accidental overdose of latanoprost eye drops.

CASE REPORT

A 71-year-old patient underwent an uncomplicated cataract surgery in his right eye. During the first postsurgical week he mistakenly used latanoprost eye drops six times daily instead of the prescribed tobramycin/dexamethasone eye drops. The patient experienced gradually decreasing visual acuity and was diagnosed with cystoid macular edema seven weeks after surgery. The cystoid macular edema resolved 4 weeks later after treatment with nepafenac 0.3% eye drops and oral acetazolamide. The cystoid macular edema recurred 2 weeks after rechallenge with latanoprost. The rechallenge-induced cystoid macular edema once again resolved after cessation of latanoprost and retreatment with nepafenac eye drops. A Naranjo assessment score of 7 was obtained, indicating a probable relationship between the patient's symptoms and the suspect drug.

摘要

目的

我们报告一例有趣的拉坦前列素滴眼液意外过量使用病例。

病例报告

一名71岁患者右眼接受了无并发症的白内障手术。术后第一周，他误将拉坦前列素滴眼液每日使用6次，而不是按处方使用妥布霉素/地塞米松滴眼液。患者视力逐渐下降，术后7周被诊断为黄斑囊样水肿。使用0.3%奈帕芬酸滴眼液和口服乙酰唑胺治疗4周后，黄斑囊样水肿消退。再次使用拉坦前列素2周后，黄斑囊样水肿复发。停用拉坦前列素并再次使用奈帕芬酸滴眼液治疗后，再次激发引起的黄斑囊样水肿再次消退。Naranjo评估得分为7分，表明患者症状与可疑药物之间可能存在关联。