Makri Olga E, Tsekouras Iasonas K, Plotas Panagiotis, Tsapardoni Foteini, Pallikari Athina, Georgakopoulos Constantine D
Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.
Curr Drug Saf. 2018;13(3):208-210. doi: 10.2174/1574886313666180619163845.
We present an interesting case of accidental overdose of latanoprost eye drops.
A 71-year-old patient underwent an uncomplicated cataract surgery in his right eye. During the first postsurgical week he mistakenly used latanoprost eye drops six times daily instead of the prescribed tobramycin/dexamethasone eye drops. The patient experienced gradually decreasing visual acuity and was diagnosed with cystoid macular edema seven weeks after surgery. The cystoid macular edema resolved 4 weeks later after treatment with nepafenac 0.3% eye drops and oral acetazolamide. The cystoid macular edema recurred 2 weeks after rechallenge with latanoprost. The rechallenge-induced cystoid macular edema once again resolved after cessation of latanoprost and retreatment with nepafenac eye drops. A Naranjo assessment score of 7 was obtained, indicating a probable relationship between the patient's symptoms and the suspect drug.
我们报告一例有趣的拉坦前列素滴眼液意外过量使用病例。
一名71岁患者右眼接受了无并发症的白内障手术。术后第一周，他误将拉坦前列素滴眼液每日使用6次，而不是按处方使用妥布霉素/地塞米松滴眼液。患者视力逐渐下降，术后7周被诊断为黄斑囊样水肿。使用0.3%奈帕芬酸滴眼液和口服乙酰唑胺治疗4周后，黄斑囊样水肿消退。再次使用拉坦前列素2周后，黄斑囊样水肿复发。停用拉坦前列素并再次使用奈帕芬酸滴眼液治疗后，再次激发引起的黄斑囊样水肿再次消退。Naranjo评估得分为7分，表明患者症状与可疑药物之间可能存在关联。
