Sule Sangeeta, Fontaine Kevin
Department of Pediatric, Pediatric Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL, USA.
Open Access Rheumatol. 2018 Jun 6;10:67-72. doi: 10.2147/OARRR.S157229. eCollection 2018.
The objective of this study was to determine the risk of obesity and metabolic syndrome in adults with a history of juvenile arthritis (JA).
Using the National Health and Nutrition Examination Survey (NHANES), we compared the characteristics of respondents with arthritis (JA vs rheumatoid arthritis [RA]) to those of the control group without arthritis. We used logistic regression analyses, controlling for age, race, and gender, to determine the ORs for metabolic syndrome.
Obesity was increased in the JA group with 67% respondents having body mass index ≥30 kg/m vs 55% respondents in the no arthritis cohort (=0.004). In unadjusted analyses, there was increased odds of metabolic syndrome in JA (OR 6.2, =0.001) and RA groups compared to those without arthritis (OR 7.7, =0.001). After adjusting for age, gender, and race, the odds of metabolic syndrome remained increased in JA (OR 5.2, =0.001) and RA (OR 3.2, =0.001) groups.
Adults with a history of JA have a significantly increased risk of metabolic syndrome compared to those without arthritis. These findings are important because metabolic syndrome has been associated with an increased risk of cardiovascular disease and death in other populations.
本研究的目的是确定有幼年特发性关节炎（JA）病史的成年人患肥胖症和代谢综合征的风险。
利用美国国家健康与营养检查调查（NHANES），我们将患有关节炎的受访者（幼年特发性关节炎与类风湿性关节炎[RA]）的特征与无关节炎的对照组进行了比较。我们使用逻辑回归分析，对年龄、种族和性别进行控制，以确定代谢综合征的比值比（OR）。
幼年特发性关节炎组肥胖率上升，67%的受访者体重指数≥30kg/m²，而无关节炎队列中的这一比例为55%（P=0.004）。在未经调整的分析中，与无关节炎者相比，幼年特发性关节炎组（OR 6.2，P=0.001）和类风湿性关节炎组代谢综合征的患病几率增加（OR 7.7，P=0.001）。在对年龄、性别和种族进行调整后，幼年特发性关节炎组（OR 5.2，P=0.001）和类风湿性关节炎组（OR 3.2，P=0.001）代谢综合征的患病几率仍然增加。
与无关节炎的成年人相比，有幼年特发性关节炎病史的成年人患代谢综合征的风险显著增加。这些发现很重要，因为在其他人群中，代谢综合征与心血管疾病和死亡风险增加有关。
