Thierry Sigrid, Fautrel Bruno, Lemelle Irène, Guillemin Francis
Université de Lorraine, Université Paris-Descartes, EA 4360 Apemac, 54500 Nancy, France.
AP-HP, Groupe hospitalier Pitié-Salpêtrière, Service de Rhumatologie, 75013 Paris, France; Université Pierre-et-Marie-Curie-Paris VI, GRC 08, 75013 Paris, France.
Joint Bone Spine. 2014 Mar;81(2):112-7. doi: 10.1016/j.jbspin.2013.09.003. Epub 2013 Nov 6.
To conduct a systematic literature review on incidence and prevalence of juvenile idiopathic arthritis and to estimate these figures in Europe for 2010.
Articles on incidence or prevalence of juvenile idiopathic arthritis were searched in Medline. Pooled incidence and prevalence were calculated overall, by gender, age, classification and arthritis categories. We used the available age and gender pooled rates to standardize the incidence and prevalence on the 2010 European population and estimate the number of cases in Europe in 2010.
Forty-three articles (33 on incidence, 29 on prevalence) were included. Incidence rates varied from 1.6 to 23 and prevalence from 3.8 to 400/100,000. Pooled incidence and prevalence were higher for girls (10.0 [9.4-10.7] and 19.4 [18.3-20.6]/100,000) than boys (5.7 [5.3-6.2] and 11.0 [10.2-11.9]/100,000). Oligoarthritis was the most frequent form (pooled incidence rate 3.7 [3.5-3.9] and prevalence 16.8 [15.9-17.7]/100,000). The direct standardized incidence rate was 8.2 [7.5-9.0] and prevalence 70.2 [62.9-78.1]/100,000. In Europe in 2010, the estimated number of incident cases was 6896 [5481-8578] and 59,175 [44,256-76,983] prevalent cases.
Incidence and prevalence varied greatly among published reports of juvenile idiopathic arthritis, which may be explained by methodological issues, classification used, and time. Estimating the number of affected children can be useful, especially with the new treatment possibilities.
对青少年特发性关节炎的发病率和患病率进行系统的文献综述，并估算2010年欧洲的这些数据。
在Medline中检索关于青少年特发性关节炎发病率或患病率的文章。总体、按性别、年龄、分类和关节炎类别计算合并发病率和患病率。我们使用现有的年龄和性别合并率对2010年欧洲人口的发病率和患病率进行标准化，并估算2010年欧洲的病例数。
纳入43篇文章（33篇关于发病率，29篇关于患病率）。发病率从1.6至23/10万不等，患病率从3.8至400/10万不等。女孩的合并发病率和患病率（分别为10.0 [9.4 - 10.7]和19.4 [18.3 - 20.6]/10万）高于男孩（分别为5.7 [5.3 - 6.2]和11.0 [10.2 - 11.9]/10万）。少关节炎是最常见的类型（合并发病率为3.7 [3.5 - 3.9]/10万，患病率为16.8 [15.9 - 17.7]/10万）。直接标准化发病率为8.2 [7.5 - 9.0]/10万，患病率为70.2 [62.9 - 78.1]/10万。2010年在欧洲，估计新发病例数为6896 [5481 - 8578]例，现患病例数为59,175 [44,256 - 76,983]例。
在已发表的青少年特发性关节炎报告中，发病率和患病率差异很大，这可能是由方法学问题、所用分类和时间等因素导致的。估算受影响儿童的数量可能会有所帮助，尤其是考虑到新的治疗可能性。
