Patel Soha, Louis Judette M
Resident.
Assistant Professor, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, Florida, US.
Eur Endocrinol. 2013 Aug;9(2):121-124. doi: 10.17925/EE.2013.09.02.121. Epub 2013 Aug 23.
The role of obstructive sleep apnoea (OSA) in pregnancy is not well studied, but an increasing body of literature appears to indicate that there may be adverse maternal and foetal health effects of the disease. OSA is associated with a twofold risk of pre-eclampsia. The small size of the existing investigations still leave unanswered questions about the consequences of OSA as it relates to some other clinically relevant outcomes such as eclampsia, stillbirth and maternal mortality. A consistent body of literature has emerged demonstrating an increased risk of insulin resistance and diabetes associated with OSA. However, among pregnant women, the association appears to be related to short sleep duration. Well-designed and adequately powered studies are needed to further delineate the role of OSA and sleep duration on pregnancy outcome and the mechanisms of those effects.
阻塞性睡眠呼吸暂停（OSA）在妊娠中的作用尚未得到充分研究，但越来越多的文献似乎表明，该疾病可能对母婴健康产生不良影响。OSA与子痫前期风险增加两倍相关。现有研究规模较小，对于OSA与子痫、死产和孕产妇死亡等其他临床相关结局的关系仍存在未解答的问题。已有一系列文献表明，OSA会增加胰岛素抵抗和糖尿病的风险。然而，在孕妇中，这种关联似乎与睡眠时间短有关。需要设计良好且有足够样本量的研究，以进一步阐明OSA和睡眠时间对妊娠结局的作用及其影响机制。
