罗马尼亚孕妇乙型肝炎病毒感染标志物的血清流行率研究：结果与预防机会
A seroprevalence study for hepatitis B virus markers of infection in pregnant women in Romania: results and opportunities for prevention.
作者信息
Popovici Odette, Radu Rodica, Romaniuc Angela, Azoicăi Doina
机构信息
National Institute of Public Health (NIPH), Bucharest;PhD student, University of Medicine and Farmacy "Grigore T.Popa" Iasi, Romania.
National Institute of Public Health (NIPH), Bucharest, Romania.
出版信息
J Gastrointestin Liver Dis. 2018 Jun;27(2):133-137. doi: 10.15403/jgld.2014.1121.272.hpb.
BACKGROUND AND AIMS
The Action Plan for viral hepatites in the WHO European Region aims to eliminate them as a public health threat by the end of 2030. The hepatitis B virus (HBV) perinatal transmission is a problem of major concern. The aim of our study was to estimate the prevalence of HBV markers in pregnant women in Romania, as scientific evidence for recommending public health interventions.
METHODS
The serum samples were prospectively collected in randomly selected maternities, from pregnant women admitted for birth beginning with July 1st, 2016. Signed informed consent was requested and the confidentiality of personal data was assured. The laboratory investigations were performed in two regional public health laboratories.
RESULTS
The prevalence of HBsAg was 5.1%. Among HBsAg positives, the HBeAg was present in 7.4% and the anti-HBeAb were detected in 55.6% of the pregnant women.
CONCLUSION
The results of the study were comparable to those in 2013 for the women of the same age group, which proves the need for established public health interventions leading to reducing, and halting HBV transmission in the population. .
背景与目的
世界卫生组织欧洲区域病毒性肝炎行动计划旨在到2030年底消除病毒性肝炎对公共卫生的威胁。乙型肝炎病毒（HBV）围产期传播是一个备受关注的问题。我们研究的目的是估计罗马尼亚孕妇中HBV标志物的流行率，为推荐公共卫生干预措施提供科学依据。
方法
从2016年7月1日起，在随机选择的产科前瞻性收集血清样本，样本来自入院分娩的孕妇。要求签署知情同意书，并确保个人数据的保密性。实验室检测在两个区域公共卫生实验室进行。
结果
HBsAg的流行率为5.1%。在HBsAg阳性孕妇中，HBeAg阳性率为7.4%，抗-HBeAb检出率为55.6%。
结论
该研究结果与2013年同年龄组女性的结果相当，这证明有必要实施既定公共卫生干预措施，以减少并阻止人群中的HBV传播。
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