大鼠植入微孔滤膜部位的恶性纤维组织细胞瘤
Malignant fibrous histiocytoma in rats at sites of implanted millipore filters.
作者信息
Greaves P, Martin J M, Rabemampianina Y
出版信息
Am J Pathol. 1985 Aug;120(2):207-14.
Abstract
Soft-tissue tumors developing in rats at the site of implanted Millipore filters showed the structural, cytochemical, and biologic characteristics of the malignant fibrous histiocytomas occurring in man. Evidence from this tumor model suggests that malignant fibrous histiocytomas can arise from pluripotential mesenchymal stem cells which are not derived from the mononuclear/phagocytic system and that chronic inflammation and scarring may predispose to their development.
摘要
在植入微孔滤膜部位生长于大鼠体内的软组织肿瘤，表现出人类恶性纤维组织细胞瘤的结构、细胞化学及生物学特征。来自该肿瘤模型的证据表明，恶性纤维组织细胞瘤可能起源于并非源自单核/吞噬系统的多能间充质干细胞，并且慢性炎症和瘢痕形成可能易使其发生发展。
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