聚合物在大鼠体内诱发的恶性纤维组织细胞瘤。
Malignant fibrous histiocytomas induced in rats by polymers.
作者信息
Maekawa A, Ogiu T, Onodera H, Furuta K, Matsuoka C, Ohno Y, Tanigawa H, Salmo G S, Matsuyama M, Hayashi Y
出版信息
J Cancer Res Clin Oncol. 1984;108(3):364-5. doi: 10.1007/BF00390475.
Five polymeric materials (3 polyvinyl chlorides, 1 polyhydroxyethyl methacrylate, and 1 dimethyl polysiloxane) were implanted into subcutaneous (SC) tissues of rats. Subcutaneous tumors developed in all experimental groups. The incidences of the tumors differed however, although the experimental conditions were the same for all these materials. This result indicates that chemical characteristics of the materials may influence the incidence of SC tumors. From the histological and electron-microscopic findings many of these tumors were diagnosed as malignant fibrous histiocytomas.
将五种聚合材料（3种聚氯乙烯、1种聚甲基丙烯酸羟乙酯和1种二甲基聚硅氧烷）植入大鼠皮下组织。所有实验组均出现皮下肿瘤。然而，尽管所有这些材料的实验条件相同，但肿瘤的发生率有所不同。这一结果表明，材料的化学特性可能会影响皮下肿瘤的发生率。根据组织学和电子显微镜检查结果，其中许多肿瘤被诊断为恶性纤维组织细胞瘤。
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