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[旁路植入术后一年的结果]

[One-year results after Cypass implantation].

作者信息

Fili S, Seddig S, Papadopoulou E, Kohlhaas M

机构信息

Klinik für Augenheilkunde, St.-Johannes-Hospital in Dortmund, Johannesstr. 9-13, 44137, Dortmund, Deutschland.

出版信息

Ophthalmologe. 2019 May;116(5):447-455. doi: 10.1007/s00347-018-0745-6.

Abstract

BACKGROUND

The Cypass Microstent (Transcend Medical, Menlo Park, CA, USA) is a biocompatible polyamide implant that is implanted in the suprachoroidal space and improves the flow of the aqueous humour via the uveoscleral pathway.

MATERIAL AND METHODS

In a retrospective clinical study 162 patients (220 eyes) with an average age of 71.8 (±14.2) years with a mild to moderate glaucoma were treated with a Cypass implant. In the study three groups of patients (group 1, group 2 and group 3) were formed. Group 1 included patients with pseudophakia who received a Cypass implant, group 2 consisted of patients with a Cypass implant combined with phacoemulsification and implantation of an intraocular lens (Phako/HKL) and group 3 included patients who had had multiple eye surgeries before the Cypass implantation. The follow-up period of the study was 1 year.

RESULTS

The mean preoperative intraocular pressure (IOP) in group 1 was 20.0 (±8.4) mm Hg and in group 2 was 20.8 (±8.7) mm Hg. The mean IOP fell to 17.7 (±7.1) mm Hg in group 1 (pressure reduction: 11.7%, p < 0.05) and in group 2 to 18.0 (±7.0) mm Hg (pressure reduction: 13.4%, p > 0.05) 12 months postoperatively. The decrease of IOP in group 3 after 1 year was 11.2%. In 20.5% of the cases (45 eyes), additional operative pressure reducing interventions was performed because the target pressure was not achieved.

CONCLUSION

After 1 year patients in group 2 showed a significantly similar reduction in pressure as group 1. Additionally, both groups showed a reduction in the number of locally applied antiglaucoma agents. The reduction of the IOP in group 3 was not significant after 12 months, in contrast to the other two groups.

摘要

背景

Cypass微支架(美国加利福尼亚州门洛帕克市的Transcend Medical公司生产)是一种生物相容性聚酰胺植入物,植入脉络膜上腔,通过葡萄膜巩膜途径改善房水流动。

材料与方法

在一项回顾性临床研究中,对162例(220只眼)平均年龄为71.8(±14.2)岁的轻至中度青光眼患者进行了Cypass植入治疗。研究中形成了三组患者(第1组、第2组和第3组)。第1组包括接受Cypass植入的人工晶状体眼患者,第2组由接受Cypass植入联合超声乳化和人工晶状体植入(超声乳化/人工晶状体植入)的患者组成,第3组包括在Cypass植入术前接受过多次眼部手术的患者。研究的随访期为1年。

结果

第1组术前平均眼压(IOP)为20.0(±8.4)mmHg,第2组为20.8(±8.7)mmHg。术后12个月,第1组平均眼压降至17.7(±7.1)mmHg(眼压降低:11.7%,p<0.05),第2组降至18.0(±7.0)mmHg(眼压降低:13.4%,p>0.05)。第3组1年后眼压降低11.2%。在20.5%的病例(45只眼)中,由于未达到目标眼压,进行了额外的手术降压干预。

结论

1年后,第2组患者的眼压降低情况与第1组显著相似。此外,两组局部应用抗青光眼药物的数量均有所减少。与其他两组相比,第3组术后12个月眼压降低不显著。

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