Walsh M T, Beldegreen R A, Clubb S L, Chen C L
Am J Vet Res. 1985 Jul;46(7):1584-8.
The effects of exogenous adrenocorticortrophic hormone (ACTH) on the serum corticosterone and cortisol concentrations were determined in 28 mature Moluccan cockatoos (Cacatua moluccensis), a representative of the psittacine species. Birds were randomly assigned to 4 groups (2 ACTH-treated groups and 2 saline-treated controls). Group I (10 cockatoos [5 males and 5 females] ) was given 15 IU of ACTH after blood samples (base line) were taken at 10:00 AM. Blood samples were taken again at 30 minutes and 2.5 hours after ACTH administration. Group II (10 cockatoos) was given similar treatment, but blood samples were taken at 1 and 4 hours after ACTH was administered. Groups III and IV (each of 4 birds) were given saline solution injections as controls. Blood samples were taken at 30 minutes and 2.5 hours after injection (group III) and at 1 and 4 hours after injection (group IV). All serum samples were analyzed for cortisol and corticosterone. Serum corticosterone concentration increased significantly (P less than 0.01) from base-line levels (26 ng/ml) to 108 ng/ml within 30 minutes after ACTH was administered. The high values were maintained for 3 hours and then decreased to 40 ng/ml at the end of 4 hours. Male birds seemed to respond to the ACTH treatment quickly and maintained increased concentration for a shorter period when compared with the responses seen in female birds. Serum cortisol values remained low throughout the experimental period. These results indicate that serum corticosterone was responsive to ACTH administration, but cortisol was not. In addition, there may be a difference in the responses between male and female members of the species.
在28只成熟的摩鹿加凤头鹦鹉（Cacatua moluccensis）（鹦鹉科物种的代表）中测定了外源性促肾上腺皮质激素（ACTH）对血清皮质酮和皮质醇浓度的影响。将鸟类随机分为4组（2个ACTH治疗组和2个生理盐水治疗对照组）。第一组（10只凤头鹦鹉[5只雄性和5只雌性]）在上午10:00采集血样（基线）后给予15 IU的ACTH。在给予ACTH后30分钟和2.5小时再次采集血样。第二组（10只凤头鹦鹉）给予类似治疗，但在给予ACTH后1小时和4小时采集血样。第三组和第四组（每组4只鸟）给予生理盐水注射作为对照。在注射后30分钟和2.5小时（第三组）以及注射后1小时和4小时（第四组）采集血样。所有血清样本均分析皮质醇和皮质酮。给予ACTH后30分钟内，血清皮质酮浓度从基线水平（26 ng/ml）显著增加（P小于0.01）至108 ng/ml。高值维持3小时，然后在4小时结束时降至40 ng/ml。与雌性鸟类相比，雄性鸟类似乎对ACTH治疗反应迅速，且浓度升高维持的时间较短。在整个实验期间，血清皮质醇值一直较低。这些结果表明，血清皮质酮对给予ACTH有反应，但皮质醇没有。此外，该物种的雄性和雌性成员之间的反应可能存在差异。
