通过羰基化环化合成天然产物。
Natural product syntheses via carbonylative cyclizations.
机构信息
Department of Chemistry, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
Nat Prod Rep. 2019 Jan 1;36(1):174-219. doi: 10.1039/c8np00033f. Epub 2018 Jun 20.
Covering: 2000-2018In this review, we highlight recent examples of natural product total syntheses employing transition metal-mediated/catalyzed carbonylative cyclization strategies to build key ring systems. It mainly covers carbonylative cyclizations for the construction of O-heterocycles, N-heterocycles and carbocycles including cyclic ketones and phenols. The reaction types include carbonylation of epoxide to β-lactones, carbonylative (macro)lactonization/lactamization, the Semmelhack reaction, tandem hydroformylation-cyclization, the Pauson-Khand reaction, carbonylative C-H activation cyclization, the Stille/Suzuki carbonylation, [n + m + 1] carbonylative cycloaddition, the Dötz annulation, and others.
涵盖年份
2000-2018 年
在这篇综述中，我们强调了最近利用过渡金属介导/催化的羰基化环化策略构建关键环系的天然产物全合成的例子。它主要涵盖了用于构建 O-杂环、N-杂环和碳环（包括环状酮和苯酚）的羰基化环化反应。反应类型包括环氧化物的羰基化合成β-内酰胺、羰基化（大环）内酯化/内酰胺化、Semmelhack 反应、串联氢甲酰化-环化、Pauson-Khand 反应、羰基化 C-H 活化环化、Stille/Suzuki 羰基化、[n + m + 1] 羰基化环加成、Dötz 环化等。
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