Linkesch W, Pavelka R, Kofler E, Müller M
Acta Med Austriaca Suppl. 1979;6:368-72.
In 130 pregnant women (41 without complications, 40 with prematurity, 49 with EPH-Gestosis) Serumferritin, ferrochelatase (FCH), delta-aminolaevulinic-aciddehydratase (D-ALA-D), porphobilinogendeaminase (PBG-D) as well as hematologic routine parameters were measured. Regarding serumferritin, both uncomplicated and cases with pathologic conditions revealed a significant decrease in group II (28th week of pregnancy) as compared to group I (12th to 28th week of pregnancy). Women with EPH-Gestosis showed the lowest values. Activities of hemesynthesizing enzymes did not show any significant differences, neither between the two groups nor between uncomplicated and pathologic cases. Compared to healthy, non pregnant women; in pregnant women we found a significant increase in D-ALA-D and PBG-D, but a significant decrease in FCH. Enzyme pattern in pregnancy reveals an increased synthesis of porphobilinogen and an increased conversion of porphobilinogen to porphyrin. The low activity of FCH we measured in our study could be a reason for the elevation of free protoporphyrin in the erythrocytes.
对130名孕妇（41名无并发症、40名早产、49名患妊娠高血压综合征）测定了血清铁蛋白、亚铁螯合酶（FCH）、δ-氨基-γ-酮戊酸脱水酶（D-ALA-D）、胆色素原脱氨酶（PBG-D）以及血液学常规参数。关于血清铁蛋白，与第一组（妊娠12至28周）相比，无并发症组和病理状况组在第二组（妊娠28周）时均显著降低。患妊娠高血压综合征的女性血清铁蛋白值最低。血红素合成酶的活性在两组之间以及无并发症和病理状况病例之间均未显示出任何显著差异。与健康未孕女性相比，孕妇的D-ALA-D和PBG-D显著升高，但FCH显著降低。妊娠时的酶谱显示胆色素原合成增加以及胆色素原向卟啉的转化增加。我们在研究中测得的FCH低活性可能是红细胞中游离原卟啉升高的一个原因。
