Kubek A
Acta Haematol Pol. 1977 Oct-Dec;8(4):263-8.
In 35 male subjects with long-standing exposure to low concentrations of nitrogen oxides the morphotic elements of peripheral blood, the activity of delta-aminolaevulinic acid dehydratase(ALA-D) in erythrocytes and urinary elimination of delta-aminolaevulinic acid (ALA), coproporphyrin (CP) and porphobilinogen (PBG) were determined. The control group comprised 29 healthy men not exposed to toxic substances. Statistically significant methaemoglobinaemia, decreased heamoglobin concentration and reduced mean heamoglobin weight in erythrocytes were found in the exposed subjects. At the same time the activity of ALA-D in erythrocytes was increased and urinary elimination of coproporphyrin was increased while that of ALA was decreased. Decreased haemoglobin concentration in peripheral blood in cases of chronic exposure to nitrogen oxides may depend on their effect on the enzymes participating in haeme synthesis. However, increased ALA-D activity in erythrocytes found in these cases may be of some importance in evaluation of exposure to nitrogen oxides.
对35名长期暴露于低浓度氮氧化物的男性受试者，测定其外周血的形态学成分、红细胞中δ-氨基乙酰丙酸脱水酶（ALA-D）的活性以及尿中δ-氨基乙酰丙酸（ALA）、粪卟啉（CP）和胆色素原（PBG）的排泄情况。对照组由29名未接触有毒物质的健康男性组成。在暴露组受试者中发现有统计学意义的高铁血红蛋白血症、血红蛋白浓度降低以及红细胞平均血红蛋白量减少。同时，红细胞中ALA-D的活性增加，粪卟啉的尿排泄量增加，而ALA的尿排泄量减少。慢性暴露于氮氧化物情况下外周血血红蛋白浓度降低可能取决于它们对参与血红素合成的酶的影响。然而，在这些情况下红细胞中ALA-D活性增加在评估氮氧化物暴露方面可能具有一定意义。
