Field H J
Antiviral Res. 1985 Jun;5(3):157-68. doi: 10.1016/0166-3542(85)90048-8.
Pseudorabies virus (PRV) infection was established in mice by means of inoculating the ear flap. The infection was universally fatal once clinical signs appeared. Bromovinyldeoxyuridine (BVDU) was a potent inhibitor of PRV in vitro, but this drug failed to protect mice and produced only marginal reductions in virus titre and slight prolongation of survival. Acyclovir (ACV) and dihydroxypropoxymethylguanine (DHPG) were both less active than BVDU when tested against the virus in BHK cells, yet DHPG therapy was extremely effective in mice; it reduced virus titres markedly and resulted in the long-term survival of mice given a potentially lethal infection. When ACV and DHPG were tested in vitro using murine rather than hamster cells, these compounds, especially DHPG, were shown to be much more active against PRV.
通过耳背接种在小鼠中建立伪狂犬病病毒（PRV）感染。一旦出现临床症状，感染通常是致命的。溴乙烯脱氧尿苷（BVDU）在体外是PRV的有效抑制剂，但该药物未能保护小鼠，仅使病毒滴度略有降低，存活时间稍有延长。阿昔洛韦（ACV）和二羟基丙氧基甲基鸟嘌呤（DHPG）在BHK细胞中针对该病毒进行测试时，活性均低于BVDU，但DHPG疗法在小鼠中极为有效；它显著降低了病毒滴度，并使受到潜在致命感染的小鼠长期存活。当使用鼠细胞而非仓鼠细胞在体外测试ACV和DHPG时，这些化合物，尤其是DHPG，对PRV的活性要高得多。
