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成人隐匿性社区获得性肺炎克雷伯菌化脓性脑膜炎:一例报告

Occult community acquired Klebsiella pneumoniae purulent meningitis in an adult: A case report.

作者信息

Yang Kai-Chuang, Shrestha Tejashwi, Kolakshyapati Manish, Shi Ling-Fei, Wang Zheng, Li Min, Lou Lin, Zhou Jia

机构信息

Department of Neurosurgery, Zhejiang Provincial People's Hospital & People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China Department of Clinical Neuroscience and Therapeutics Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Department of Geriatrics Department of Neurosurgery & Gamma Knife Center, Zhejiang Provincial People's Hospital & People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

出版信息

Medicine (Baltimore). 2018 Jun;97(25):e11017. doi: 10.1097/MD.0000000000011017.

Abstract

RATIONALE

Klebsiella pneumonia (K. pneumonia), primarily a hospital-acquired pathogen, can cause a variety of deep-seated infections with significant morbidities. However, in the current scenario of global rise in antibiotic abuse, unexpected infection could be caused by K. pneumoniae.

PATIENT CONCERNS

A 56-year-old male who presented with intermittent headache and low fever was admitted, he had transsphenoidal surgery for pituitary adenoma 3 years ago. Routine laboratory tests revealed an elevated WBC count of 10.12 × 10/L and C-reactive protein (CRP) 12.9 mg/L. computed tomography (CT) revealed the sellar region with suspicious hemorrhage.

DIAGNOSES

The patient was initially diagnosed with acute residual tumor hemorrhage. But the consequent diagnose of Klebsiella pneumoniae purulent meningitis was made based on the cerebrospinal fluid lab test and cerebrospinal fluid (CSF) and blood culture, and CT scan.

INTERVENTIONS

Lumbar puncture examination was made and the antibiotics were adjusted to meropenem and vancomycin according to the antibiotic sensitivity test. But because of the patient's unstable vital signs, his family refuse further lateral ventricular drainage.

OUTCOMES

The infection was out of control and the patient died of spontaneous breath and heartbeat arrest.

LESSONS

Through this case, we could learn that any clue of suspicious intracranial infection should be carefully considered in the current scenario of global rise in antibiotic abuse. The manifestation of intermittent headache and mild fever could be potential signs of fatal infection, and prompt appropriate measures should be taken timely.

摘要

原理

肺炎克雷伯菌主要是一种医院获得性病原体,可引起各种具有显著发病率的深部感染。然而,在当前全球抗生素滥用增加的情况下,肺炎克雷伯菌可能导致意想不到的感染。

患者情况

一名56岁男性因间歇性头痛和低热入院,他3年前因垂体腺瘤接受了经蝶窦手术。常规实验室检查显示白细胞计数升高至10.12×10/L,C反应蛋白(CRP)为12.9mg/L。计算机断层扫描(CT)显示鞍区有可疑出血。

诊断

患者最初被诊断为急性残留肿瘤出血。但随后根据脑脊液实验室检查、脑脊液(CSF)和血培养以及CT扫描,诊断为肺炎克雷伯菌化脓性脑膜炎。

干预措施

进行了腰椎穿刺检查,并根据药敏试验将抗生素调整为美罗培南和万古霉素。但由于患者生命体征不稳定,其家属拒绝进一步进行侧脑室引流。

结果

感染失控,患者死于自主呼吸和心跳骤停。

经验教训

通过这个病例,我们可以了解到,在当前全球抗生素滥用增加的情况下,任何可疑颅内感染的线索都应仔细考虑。间歇性头痛和低热的表现可能是致命感染的潜在迹象,应及时采取适当措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ac/6024475/027c63a32e60/medi-97-e11017-g001.jpg

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