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睾丸间质细胞瘤的治疗:一例报告。

Management of testicular Leydig cell tumor: A case report.

作者信息

Zhu Jianguo, Luan Yun, Li Haige

机构信息

Department of Radiology, the Second Affiliated Hospital of Nanjing Medical University Department of Ultrasound, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.

出版信息

Medicine (Baltimore). 2018 Jun;97(25):e11158. doi: 10.1097/MD.0000000000011158.

DOI:10.1097/MD.0000000000011158
PMID:29924022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6023788/
Abstract

RATIONALE

Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors.

PATIENT CONCERNS

We highlight the imaging phenotype, as well as the pathological findings of a case of LCT in a 62-year-old male.

DIAGNOSES

Preoperative noncontrast CT scan of the abdomen revealed a 7.0 × 6.4 × 5.3 cm oval mass with heterogeneous density, located in the right testis. Pelvic noncontrast MRI showed a heterogeneous mass on T1-weighted and T2-weighted images. The solid part of the tumor exhibited high signal on the diffusion-weighted imaging, and an obvious enhancement on the contrast-enhanced MR imaging. Ultrasonography examination demonstrated a large mixed echogenic space occupying lesion involving the whole right testis with multiple cystic areas and increased vascularity. This patient underwent radical orchiectomy. The pathologic diagnosis was LCT.

INTERVENTIONS

This patient underwent operative resection of the tumor. Due to the negative resection margins and absence of distant metastases, the patient did not receive additional radiotherapy or chemotherapy.

OUTCOMES

Four months after the surgery, the follow-up CT-scan did not reveal any local recurrence and distant metastases.

LESSONS

This case improves our ability to detect and diagnose LCT by summarizing its imaging characteristics as well as reviewing the literature. Additionally, we described the state-of-the-art management of the management of this rare tumor.

摘要

原理

睾丸间质细胞瘤(LCT)是一种罕见的肿瘤。它通常表现为无痛性睾丸肿块,伴有或不伴有内分泌改变。组织学和免疫组织化学检查在鉴别LCT与睾丸生殖细胞肿瘤方面发挥着重要作用。

患者情况

我们重点介绍了一名62岁男性LCT病例的影像学表现及病理结果。

诊断

术前腹部非增强CT扫描显示右侧睾丸有一个7.0×6.4×5.3 cm的椭圆形肿块,密度不均匀。盆腔非增强MRI在T1加权和T2加权图像上显示为不均匀肿块。肿瘤实性部分在扩散加权成像上呈高信号,在对比增强MRI上有明显强化。超声检查显示一个巨大的混合回声占位性病变累及整个右侧睾丸,有多个囊性区域且血管增多。该患者接受了根治性睾丸切除术。病理诊断为LCT。

干预措施

该患者接受了肿瘤手术切除。由于切缘阴性且无远处转移,患者未接受额外的放疗或化疗。

结果

术后4个月,随访CT扫描未发现任何局部复发和远处转移。

经验教训

通过总结其影像学特征并回顾文献,该病例提高了我们检测和诊断LCT的能力。此外,我们描述了这种罕见肿瘤的最新治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/3b793bb612b3/medi-97-e11158-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/07ffa8f9b59c/medi-97-e11158-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/5185fef3e224/medi-97-e11158-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/fbd9ee5b9e45/medi-97-e11158-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/3b793bb612b3/medi-97-e11158-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/07ffa8f9b59c/medi-97-e11158-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/5185fef3e224/medi-97-e11158-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/fbd9ee5b9e45/medi-97-e11158-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a9f/6023788/3b793bb612b3/medi-97-e11158-g004.jpg

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Pan Afr Med J. 2017 May 19;27:51. doi: 10.11604/pamj.2017.27.51.10571. eCollection 2017.
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Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature.伴有横纹肌肉瘤的支持-间质细胞瘤:三例报告并文献复习
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