Haydar Hasan, Qatza Ayham, Karaja Saja, Alkhleef Anagheem, Lutfi Mohamad Yasin, Jarbouh Habib
Faculty of Medicine, Hama University, Hama, Syrian Arab Republic.
Hama National Hospital, Internal Medicine Department, Hama, Syrian Arab Republic.
Urol Case Rep. 2025 Jan 2;58:102927. doi: 10.1016/j.eucr.2024.102927. eCollection 2025 Jan.
Leydig cell tumors (LCTs) are rare testicular neoplasms, representing 1-3% of all testicular tumors. A 65-year-old male presented with a painless left scrotal mass. Ultrasound revealed a 61 × 53 × 35 mm tumor with heterogeneous echogenicity and abundant blood supply. Radical orchidectomy was performed, and immunohistochemistry confirmed LCT with positivity for Inhibin A and calretinin, and negativity for CK, chromogranin, LCA, and low Ki67. Postoperative follow-up at 6 months showed improved condition, no scrotal masses, and normal tumor markers. Finally, LCTs in older males require differential diagnosis; hormonal activity impacts presentation. Conservative management and monitoring are crucial.
睾丸间质细胞瘤（LCTs）是一种罕见的睾丸肿瘤，占所有睾丸肿瘤的1%-3%。一名65岁男性因左侧阴囊无痛性肿块就诊。超声检查发现一个61×53×35mm的肿瘤，回声不均匀，血供丰富。行根治性睾丸切除术，免疫组化证实为LCT，抑制素A和钙视网膜蛋白呈阳性，细胞角蛋白、嗜铬粒蛋白、淋巴细胞共同抗原呈阴性，Ki67低表达。术后6个月随访显示病情好转，无阴囊肿块，肿瘤标志物正常。最后，老年男性的LCTs需要鉴别诊断；激素活性会影响临床表现。保守治疗和监测至关重要。
