Adewunmi C O, Ojewole J A
Arch Int Pharmacodyn Ther. 1985 Jun;275(2):231-7.
The effects of oxamniquine on neuromuscular transmission have been investigated in some experimental animals in an effort to unveil some of the unwanted effects of this commonly prescribed schistosomicide. Results obtained show that relatively low concentrations of the drug (oxamniquine, 10-100 micrograms/ml) potentiated acetylcholine-, carbachol- and nicotine-evoked contractions of the toad (Bufo regularis) isolated rectus abdominis muscle. Moderate to high concentrations of the compound (oxamniquine, 500 micrograms/ml and above) contracted rectus abdominis muscle preparations, and depressed indirect electrically-induced twitches of the rat isolated hemidiaphragm and chick isolated biventer muscle preparations. The depression of electrically-evoked twitches of the chick biventer and rat phrenic nerve-hemidiaphragm muscle preparations in vitro induced by moderate to high concentrations of oxamniquine (500 micrograms/ml and above) were resistant to bath-applied physostigmine (1-15 micrograms/ml), but deepened by d-tubocurarine (3-10 micrograms/ml). These findings suggest that the neuromuscular blocking action of oxamniquine is probably post-junctional in origin.
为了揭示这种常用的杀血吸虫剂的一些不良影响，已在一些实验动物中研究了奥沙尼喹对神经肌肉传递的影响。获得的结果表明，相对低浓度的药物（奥沙尼喹，10 - 100微克/毫升）可增强乙酰胆碱、卡巴胆碱和尼古丁诱发的蟾蜍（普通蟾蜍）离体腹直肌收缩。中等至高浓度的该化合物（奥沙尼喹，500微克/毫升及以上）可使腹直肌制剂收缩，并抑制大鼠离体半膈肌和鸡离体二腹肌制剂的间接电诱发抽搐。中等至高浓度的奥沙尼喹（500微克/毫升及以上）在体外诱导的鸡二腹肌和大鼠膈神经 - 半膈肌制剂的电诱发抽搐抑制作用对浴用毒扁豆碱（1 - 15微克/毫升）有抗性，但可被筒箭毒碱（3 - 10微克/毫升）加深。这些发现表明，奥沙尼喹的神经肌肉阻滞作用可能起源于接头后。
