Santana M S, Nascimento K P, Lotufo P A, Benseãor I M, Meotti F C
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brasil.
Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2018;51(8):e7543. doi: 10.1590/1414-431x20187543. Epub 2018 Jun 18.
Allantoin is the main product of uric acid oxidation and was found to be augmented in atherosclerotic plaque in human autopsy and in animal models of atherosclerosis. Uric acid is abundant in human plasma and is prone to oxidation in inflammatory conditions such as atherosclerosis. In this study, we found a significant increase in plasma uric acid (P=0.002) and allantoin (P=0.025) in participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) that presented common carotid intima-media thickness (c-IMT) within the 75th percentile (c-IMT≥P75). Multiple linear regression showed an association of c-IMT with uric acid (β=0.0004, P=0.014) and allantoin (β=0.018, P=0.008). This association was independent of age, the traditional risk factor LDL/HDL ratio, and non-traditional risk factors: pulse pressure, neck circumference, and the inflammatory marker myeloperoxidase. The independent and strong association of allantoin with c-IMT shows that it might be a useful marker, along with other traditional risk factors, to evaluate an early stage of atherosclerosis.
尿囊素是尿酸氧化的主要产物，在人体尸检的动脉粥样硬化斑块以及动脉粥样硬化动物模型中均发现其含量增加。尿酸在人体血浆中含量丰富，在诸如动脉粥样硬化等炎症状态下易于氧化。在本研究中，我们发现巴西成人健康纵向研究（ELSA - Brasil）中，颈总动脉内膜中层厚度（c - IMT）处于第75百分位数（c - IMT≥P75）的参与者血浆尿酸（P = 0.002）和尿囊素（P = 0.025）显著增加。多元线性回归显示c - IMT与尿酸（β = 0.0004，P = 0.014）和尿囊素（β = 0.018，P = 0.008）相关。这种关联独立于年龄、传统危险因素低密度脂蛋白/高密度脂蛋白比值以及非传统危险因素：脉压、颈围和炎症标志物髓过氧化物酶。尿囊素与c - IMT的独立且强关联表明，它可能与其他传统危险因素一起，成为评估动脉粥样硬化早期阶段的有用标志物。
