具有心力衰竭风险预后价值的新型氧化应激生物标志物
Novel Oxidative Stress Biomarkers with Risk Prognosis Values in Heart Failure.
作者信息
Ng Mei Li, Ang Xu, Yap Kwan Yi, Ng Jun Jie, Goh Eugene Chen Howe, Khoo Benjamin Bing Jie, Richards Arthur Mark, Drum Chester Lee
机构信息
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Vascular Surgery, Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, Singapore 119074, Singapore.
出版信息
Biomedicines. 2023 Mar 15;11(3):917. doi: 10.3390/biomedicines11030917.
Oxidative stress (OS) is mediated by reactive oxygen species (ROS), which in cardiovascular and other disease states, damage DNA, lipids, proteins, other cellular and extra-cellular components. OS is both initiated by, and triggers inflammation, cardiomyocyte apoptosis, matrix remodeling, myocardial fibrosis, and neurohumoral activation. These have been linked to the development of heart failure (HF). Circulating biomarkers generated by OS offer potential utility in patient management and therapeutic targeting. Novel OS-related biomarkers such as NADPH oxidases (sNox2-dp, Nrf2), advanced glycation end-products (AGE), and myeloperoxidase (MPO), are signaling molecules reflecting pathobiological changes in HF. This review aims to evaluate current OS-related biomarkers and their associations with clinical outcomes and to highlight those with greatest promise in diagnosis, risk stratification and therapeutic targeting in HF.
氧化应激（OS）由活性氧（ROS）介导，在心血管疾病和其他疾病状态下，ROS会损伤DNA、脂质、蛋白质以及其他细胞和细胞外成分。OS既由炎症引发，又会触发炎症、心肌细胞凋亡、基质重塑、心肌纤维化和神经体液激活。这些都与心力衰竭（HF）的发生发展有关。由OS产生的循环生物标志物在患者管理和治疗靶点方面具有潜在用途。新型OS相关生物标志物，如NADPH氧化酶（sNox2-dp、Nrf2）、晚期糖基化终产物（AGE）和髓过氧化物酶（MPO），是反映HF病理生物学变化的信号分子。本综述旨在评估当前与OS相关的生物标志物及其与临床结局的关联，并突出那些在HF诊断、风险分层和治疗靶点方面最具潜力的生物标志物。
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