Jüngst D, Osterholzer M, Lazik E, Karl H J
Acta Med Austriaca Suppl. 1979;6:406-9.
Determination of urinary cholesterol has been suggested to be of possible value in the diagnosis of urogenital carcinomas especially of prostate, kidney and bladder. However, it has not been proven whether this method could be used as a screening test in large numbers of patients. 430 males and 545 females with an age above 50 years were selected for the study. Total urinary cholesterol values exceeding 5.1 mg/24 hours (regarded as positive results) were present in 13 males (3%) and 9 females (1.6%). In addition to benign diseases of the kidney and the urogenital tract, 2 carcinomas of the bladder and 1 carcinoma of the kidney were detected in the male group with elevated urinary cholesterol excretion. In view of the low prevalence of urological carcinomas and the cost of urinary cholesterol determination by GLC, this method cannot be recommended as a primary screening test, but could be of practical value in populations with microscopic haematuria and increased prevalence of urological carcinomas.
尿胆固醇测定已被认为可能对泌尿生殖系统癌症，特别是前列腺癌、肾癌和膀胱癌的诊断有价值。然而，该方法是否可用于大量患者的筛查试验尚未得到证实。本研究选取了430名年龄在50岁以上的男性和545名年龄在50岁以上的女性。13名男性（3%）和9名女性（1.6%）的尿胆固醇总值超过5.1毫克/24小时（视为阳性结果）。除了肾脏和泌尿生殖道的良性疾病外，在尿胆固醇排泄升高的男性组中检测出2例膀胱癌和1例肾癌。鉴于泌尿系统癌症的低患病率以及通过气相色谱法测定尿胆固醇的成本，该方法不能作为主要筛查试验推荐，但在有镜下血尿且泌尿系统癌症患病率增加的人群中可能具有实际价值。
