Jüngst D, Osterholzer M, Tauber R, Karl H J
Urology. 1982 Nov;20(5):495-8. doi: 10.1016/0090-4295(82)90121-2.
Cholesterol determinations in morning urine samples were taken in 235 selected patients with a positive test for microscopic hematuria. Values ranged from 0.2 to 76.0 mg (median 5.5) in 23 patients with urologic malignancies and from 0.1 to 33.4 mg (median 1.1) in 38 patients with various benign diseases of the kidney or urogenital tract. In the 28 patients with urinary tract infections and 146 subjects without evidence of disorders of the kidney and the urogenital system, urinary cholesterol excretion was usually normal (0.1 to 1.9 mg; median 0.35). Using 1.0 mg urinary cholesterol per morning urine as a cutoff point, sensitivity for urologic carcinomas is about 80 per cent with a comparable high specificity of 90 per cent. Therefore, subsequent measurements of urinary cholesterol in populations with microscopic hematuria could define two groups, one with high prevalence and one with low prevalence of urologic malignancies. The less complicated colorimetric instead of gas-liquid chromatographic determination of urinary cholesterol can be recommended as a screening test for urologic carcinomas in populations with microscopic hematuria.
对235例经显微镜检查血尿试验呈阳性的选定患者采集晨尿样本进行胆固醇测定。23例患有泌尿系统恶性肿瘤的患者，其胆固醇值范围为0.2至76.0毫克（中位数为5.5）；38例患有各种肾脏或泌尿生殖道良性疾病的患者，其胆固醇值范围为0.1至33.4毫克（中位数为1.1）。在28例患有尿路感染的患者以及146例无肾脏和泌尿生殖系统疾病迹象的受试者中，尿胆固醇排泄通常正常（0.1至1.9毫克；中位数为0.35）。以晨尿中尿胆固醇1.0毫克作为临界点，对泌尿系统癌的敏感性约为80%，特异性同样高达90%。因此，对有显微镜下血尿的人群后续进行尿胆固醇测量可将其分为两组，一组泌尿系统恶性肿瘤患病率高，另一组患病率低。对于有显微镜下血尿的人群，推荐采用较简便的比色法而非气液色谱法测定尿胆固醇，作为泌尿系统癌的筛查试验。
