Foiato Tariane Friedrich, Bereza Bruno Rafael Kunz, Montenegro Marcos Flávio, Guilherme Marina Riedi, Volski Larissa Beatriz, Rebolho Juliano Camargo
Department of Oncologic Surgery, Centro de Oncologia de Cascavel, Cascavel, PR, Brazil.
Service of Skin and Melanoma, Hospital Erasto Gaertner, Curitiba, PR, Brazil.
An Bras Dermatol. 2018 Jun;93(3):332-336. doi: 10.1590/abd1806-4841.20185788.
Melanoma is one of the conditions with greater increase in incidence worldwide in recent decades. It is a skin cancer with potential high lethality and predominates in Caucasian adults. Treatment of primary cutaneous melanoma is essentially surgical and search for sentinel lymph node can modify the aggressiveness of the treatment.
To analyze the epidemiological profile of patients diagnosed with primary cutaneous melanoma, histopathological features and compare with literature data.
This is a retrospective, observational, single-center, case series study of patients with primary cutaneous melanoma, who underwent surgery between January 2008 and December 2013. The parameters include: Age, sex, clinical stage, date of surgery, tumor location, histological subtype, condition of surgical margins, Breslow thickness, mitotic index, presence of ulceration and metastasis on admission.
We included 321 melanoma patients who were treated at Hospital Erasto Gaertner. The population consisted of 58.9% females and 41.1% males with an average age of 52.8 ± 16.3 years. As for the clinical stage, 51.1% were in the initial stage, 24.3% in the clinical stage II (A, B and C), 21.2% in clinical stage III and 3.4% with distant metastases. The most frequent location of the primary melanoma was the trunk, and the histological subtype was superficial spreading pattern. Intermediate and thick melanomas were the most frequent.
This is a retrospective study and some information and data could be incomplete or absent.
The diagnosis and treatment of melanoma in early stages provides less morbidity and improved survival of patients. Understanding the biological behavior of tumor and knowing the local epidemiology guide health strategies.
黑色素瘤是近几十年来全球发病率增长幅度较大的疾病之一。它是一种具有潜在高致死率的皮肤癌，在白种成年人中占主导地位。原发性皮肤黑色素瘤的治疗主要是手术治疗，而前哨淋巴结的探查可改变治疗的激进程度。
分析原发性皮肤黑色素瘤患者的流行病学特征、组织病理学特征，并与文献数据进行比较。
这是一项回顾性、观察性、单中心病例系列研究，研究对象为2008年1月至2013年12月间接受手术治疗的原发性皮肤黑色素瘤患者。参数包括：年龄、性别、临床分期、手术日期、肿瘤位置、组织学亚型、手术切缘情况、 Breslow厚度、有丝分裂指数、入院时溃疡和转移情况。
我们纳入了在埃拉斯托·盖特纳医院接受治疗的321例黑色素瘤患者。该人群中女性占58.9%，男性占41.1%，平均年龄为52.8±16.3岁。至于临床分期，51.1%处于初始阶段，24.3%处于临床II期（A、B和C），21.2%处于临床III期，3.4%有远处转移。原发性黑色素瘤最常见的部位是躯干，组织学亚型为浅表扩散型。中等厚度和厚黑色素瘤最为常见。
这是一项回顾性研究，一些信息和数据可能不完整或缺失。
黑色素瘤的早期诊断和治疗可降低患者的发病率并提高生存率。了解肿瘤的生物学行为并知晓当地流行病学情况有助于指导健康策略。
