血小板抑制剂在正常受试者和高胆固醇血症受试者中的差异效应。
Differential effect of platelet inhibitors in normal and in hypercholesterolaemic subjects.
作者信息
Aviram M, Winterstein G, Brook J G
出版信息
Br J Clin Pharmacol. 1985 Jun;19(6):715-9. doi: 10.1111/j.1365-2125.1985.tb02705.x.
Dibutyryl cyclic AMP, forskolin, dipyridamole and butyl imidazole inhibited platelet aggregation (induced by ADP or collagen) in washed platelets more than in platelet-rich plasma preparations. Aspirin, indomethacin and epoprostenol (prostacyclin, PGI2) showed no preferential inhibition of these platelet preparations. When platelet-rich plasma from either normal or familial hypercholesterolaemic (FH) subjects was used, aspirin, indomethacin and dipyridamole (but not forskolin) inhibited platelet aggregation in normal subjects more than in FH patients. When low doses of aspirin (75 mg daily for 7 days) or dipyridamole (250 mg, single dose) were administered in vivo, platelet aggregation was inhibited more in the normal subjects in comparison to the patient group.
二丁酰环磷腺苷、福斯高林、双嘧达莫和丁基咪唑对洗涤血小板中血小板聚集（由二磷酸腺苷或胶原诱导）的抑制作用比对富含血小板血浆制剂中的抑制作用更强。阿司匹林、吲哚美辛和依前列醇（前列环素，PGI2）对这些血小板制剂没有优先抑制作用。当使用来自正常或家族性高胆固醇血症（FH）受试者的富含血小板血浆时，阿司匹林、吲哚美辛和双嘧达莫（但不是福斯高林）对正常受试者血小板聚集的抑制作用比对FH患者更强。当体内给予低剂量阿司匹林（每日75毫克，共7天）或双嘧达莫（250毫克，单次剂量）时，与患者组相比，正常受试者的血小板聚集受到的抑制作用更强。
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