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1
Differential effect of platelet inhibitors in normal and in hypercholesterolaemic subjects.血小板抑制剂在正常受试者和高胆固醇血症受试者中的差异效应。
Br J Clin Pharmacol. 1985 Jun;19(6):715-9. doi: 10.1111/j.1365-2125.1985.tb02705.x.
2
Effect of dipyridamole alone and in combination with aspirin on whole blood platelet aggregation, PGI2 generation, and red cell deformability ex vivo in man.双嘧达莫单独及与阿司匹林联合应用对人体全血血小板聚集、前列环素（PGI2）生成及离体红细胞变形性的影响。
Cardiovasc Res. 1991 Mar;25(3):177-83. doi: 10.1093/cvr/25.3.177.
3
Effects of low doses of aspirin and dipyridamole on platelet aggregation in the dog coronary artery.低剂量阿司匹林和双嘧达莫对犬冠状动脉血小板聚集的影响。
J Pharmacol Exp Ther. 1987 Jan;240(1):37-43.
4
Sub-aggregatory doses of catecholamines prevent prostacyclin-induced inhibition of platelet aggregation.儿茶酚胺的亚聚集剂量可防止前列环素诱导的血小板聚集抑制。
Am Heart J. 1985 Jun;109(6):1258-63. doi: 10.1016/0002-8703(85)90348-5.
5
Dipyridamole and aspirin in relation to platelet aggregation and vessel wall prostaglandin generation.双嘧达莫和阿司匹林与血小板聚集及血管壁前列腺素生成的关系。
J Cardiovasc Pharmacol. 1982 Jul-Aug;4(4):688-93. doi: 10.1097/00005344-198207000-00022.
6
The effects of continuous infusions of prostacyclin-Na (epoprostenol-sodium) on platelet counts, ADP-induced aggregation, and cyclic AMP levels in normal volunteers.
Prostaglandins. 1983 Aug;26(2):287-302. doi: 10.1016/0090-6980(83)90096-5.
7
Simvastatin reduces platelet thromboxane formation and restores normal platelet sensitivity against prostacyclin in type IIa hypercholesterolemia.辛伐他汀可减少血小板血栓素的形成，并恢复IIa型高胆固醇血症患者血小板对前列环素的正常敏感性。
Eicosanoids. 1989;2(1):39-45.
8
Dipyridamole potentiates the inhibition of platelet aggregation by aspirin (in human platelet rich plasma and whole blood).
J Lipid Mediat. 1991 Jul-Aug;4(1):61-7.
9
A biphasic effect of prostacyclin (PGI2) on platelet aggregation.前列环素（PGI2）对血小板聚集的双相作用。
Thromb Res. 1980 Sep 15;19(6):877-81. doi: 10.1016/0049-3848(80)90015-8.
10
Dipyridamole and other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin.双嘧达莫和其他磷酸二酯酶抑制剂通过增强内源性前列环素发挥抗血栓形成剂的作用。
Lancet. 1978 Jun 17;1(8077):1286-9. doi: 10.1016/s0140-6736(78)91269-2.

引用本文的文献

1
Platelet activation in normo- and hyperlipoproteinemias.正常脂蛋白血症和高脂蛋白血症中的血小板活化
Basic Res Cardiol. 1986 Sep-Oct;81(5):437-53. doi: 10.1007/BF01907750.

本文引用的文献

1
Aggregation of blood platelets by adenosine diphosphate and its reversal.二磷酸腺苷引起的血小板聚集及其逆转
Nature. 1962 Jun 9;194:927-9. doi: 10.1038/194927b0.
2
Effect of cholesterol on production of thromboxane b2 by platelets in vitro.胆固醇对体外血小板血栓素B2生成的影响。
N Engl J Med. 1980 Jan 3;302(1):6-10. doi: 10.1056/NEJM198001033020102.
3
Indobufen treatment in type IIA hypercholesterolemic subjects: effects on platelet function and malondialdehyde production.吲哚布芬对IIA型高胆固醇血症患者的治疗：对血小板功能和丙二醛生成的影响。
Pharmacol Res Commun. 1981 Oct;13(9):847-59. doi: 10.1016/s0031-6989(81)80045-8.
4
The effect of human plasma on platelet function in familial hypercholesterolemia.
Thromb Res. 1982 Apr 15;26(2):101-9. doi: 10.1016/0049-3848(82)90019-6.
5
Evaluation of platelet-inhibiting drugs in models of atherosclerosis.动脉粥样硬化模型中血小板抑制药物的评估。
Annu Rev Pharmacol Toxicol. 1982;22:279-95. doi: 10.1146/annurev.pa.22.040182.001431.
6
Platelets and atherosclerosis.血小板与动脉粥样硬化。
Am J Med. 1981 Sep;71(3):331-3. doi: 10.1016/0002-9343(81)90144-3.
7
Platelet function studies in coronary heart disease: VIII. Decreased platelet sensitivity to prostacyclin in patients with myocardial ischaemia.冠心病中的血小板功能研究：VIII. 心肌缺血患者血小板对前列环素的敏感性降低。
Thromb Res. 1980;18(1-2):273-7. doi: 10.1016/0049-3848(80)90193-0.
8
Platelets intravascular coagulation and fibrinolysis in hyperlipidaemias: relationship to thrombo-embolic complications.高脂血症中的血小板血管内凝血与纤维蛋白溶解：与血栓栓塞并发症的关系
Acta Med Scand Suppl. 1980;642:101-12. doi: 10.1111/j.0954-6820.1980.tb10941.x.
9
Platelet interaction with high and low density lipoproteins.血小板与高密度脂蛋白和低密度脂蛋白的相互作用。
Atherosclerosis. 1983 Mar;46(3):259-68. doi: 10.1016/0021-9150(83)90176-4.
10
Platelet function and lipoprotein levels after plasma-exchange in patients with familial hypercholesterolaemia.家族性高胆固醇血症患者血浆置换后的血小板功能和脂蛋白水平
Clin Sci (Lond). 1983 Jun;64(6):637-42. doi: 10.1042/cs0640637.

血小板抑制剂在正常受试者和高胆固醇血症受试者中的差异效应。

Differential effect of platelet inhibitors in normal and in hypercholesterolaemic subjects.

作者信息

Aviram M, Winterstein G, Brook J G

出版信息

Br J Clin Pharmacol. 1985 Jun;19(6):715-9. doi: 10.1111/j.1365-2125.1985.tb02705.x.

DOI:10.1111/j.1365-2125.1985.tb02705.x
PMID:2992558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463878/
Abstract

Dibutyryl cyclic AMP, forskolin, dipyridamole and butyl imidazole inhibited platelet aggregation (induced by ADP or collagen) in washed platelets more than in platelet-rich plasma preparations. Aspirin, indomethacin and epoprostenol (prostacyclin, PGI2) showed no preferential inhibition of these platelet preparations. When platelet-rich plasma from either normal or familial hypercholesterolaemic (FH) subjects was used, aspirin, indomethacin and dipyridamole (but not forskolin) inhibited platelet aggregation in normal subjects more than in FH patients. When low doses of aspirin (75 mg daily for 7 days) or dipyridamole (250 mg, single dose) were administered in vivo, platelet aggregation was inhibited more in the normal subjects in comparison to the patient group.

摘要

二丁酰环磷腺苷、福斯高林、双嘧达莫和丁基咪唑对洗涤血小板中血小板聚集（由二磷酸腺苷或胶原诱导）的抑制作用比对富含血小板血浆制剂中的抑制作用更强。阿司匹林、吲哚美辛和依前列醇（前列环素，PGI2）对这些血小板制剂没有优先抑制作用。当使用来自正常或家族性高胆固醇血症（FH）受试者的富含血小板血浆时，阿司匹林、吲哚美辛和双嘧达莫（但不是福斯高林）对正常受试者血小板聚集的抑制作用比对FH患者更强。当体内给予低剂量阿司匹林（每日75毫克，共7天）或双嘧达莫（250毫克，单次剂量）时，与患者组相比，正常受试者的血小板聚集受到的抑制作用更强。