去甲丙咪嗪治疗期间的血浆褪黑素：去甲肾上腺素能传递变化的证据。
Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission.
作者信息
Cowen P J, Green A R, Grahame-Smith D G, Braddock L E
出版信息
Br J Clin Pharmacol. 1985 Jun;19(6):799-805. doi: 10.1111/j.1365-2125.1985.tb02717.x.
Abstract
Plasma melatonin was used to determine overall beta-adrenergic transmission through pineal neuro-effector junctions during desmethylimipramine (DMI) treatment in 10 normal subjects. Changes in plasma melatonin indicated that an initial increase in noradrenaline (NA) transmission produced by DMI was counteracted by adaptive changes which restored transmission to normal by the third week of treatment. A 'rebound' increase in NA transmission was seen on DMI withdrawal. The results suggest that the adaptive changes which occur in NA synapses during DMI treatment do not, as has been proposed, decrease NA transmission below normal levels, but instead restore homeostasis in the presence of the drug.
摘要
在10名正常受试者接受去甲丙咪嗪（DMI）治疗期间，血浆褪黑素被用于测定通过松果体神经效应器连接的整体β-肾上腺素能传递。血浆褪黑素的变化表明，DMI引起的去甲肾上腺素（NA）传递最初增加被适应性变化抵消，这些适应性变化在治疗第三周时将传递恢复到正常水平。在停用DMI时观察到NA传递出现“反跳”增加。结果表明，DMI治疗期间NA突触中发生的适应性变化并非如所提出的那样将NA传递降低至正常水平以下，而是在药物存在的情况下恢复体内平衡。
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本文引用的文献
1
24-hour profiles of melatonin, cortisol, insulin, C-peptide and GIP following a meal and subsequent fasting.
Clin Endocrinol (Oxf). 1982 Jan;16(1):89-95. doi: 10.1111/j.1365-2265.1982.tb03151.x.
2
Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content.急性和慢性给予抗抑郁药对可乐定引起的大鼠脑3-甲氧基-4-羟基苯乙二醇硫酸盐含量降低的影响。
Life Sci. 1981 Jan 26;28(4):377-84. doi: 10.1016/0024-3205(81)90082-5.
3
Antidepressant drugs elevate rat pineal and plasma melatonin.抗抑郁药物可提高大鼠松果体和血浆褪黑素水平。
Experientia. 1980 Apr 15;36(4):442-4. doi: 10.1007/BF01975137.
4
5
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6
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Clin Chem. 1983 Feb;29(2):396-7.
7
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